Investigations on pathophysiological mechanisms, the clinical relevance and therapeutic controllability of hyperkalemia in neonatal diarrheic calves

犊牛新生儿腹泻是一种常见的经济上重要的疾病。代谢紊乱在这些动物中很常见，通常以代谢性酸中毒、血液浓缩和电解质失衡为特征。高钾血症是在这些小牛中经常观察到的一种紊乱，传统上归因于酸血症状态下钾离子的细胞内易位受损，并且由于其潜在的心脏毒性而与危及生命的心律失常相关。因此，认为血浆钾浓度升高是新生儿腹泻小牛死亡的重要原因。 自己的研究表明，这种电解质紊乱的临床表现也以站立能力受损和明显的临床脱水为特征，后者似乎在高钾血症的发病机制中起关键作用。基于这些研究，本项目将解决高钾血症的治疗可控性，并旨在确定参与恢复钾稳态的潜在机制。该项目的第二个目的是填补关于腹泻新生小牛高钾血症的发病机制和临床相关性的知识空白。

Neonatal diarrhea in calves represents a common and economically important disease. Metabolic disorders are common in those animals and are typically characterized by metabolic acidosis, hemoconcentration and electrolyte imbalances. Hyperkalemia is a frequently observed disturbance in such calves that was traditionally attributed to impaired intracellular translocation of potassium ion in an acidemic state and was associated with life-threatening cardiac arrhythmias due to its potential cardiotoxicity. Elevated plasma potassium concentrations were therefore considered to be an important cause of death in calves with neonatal diarrhea. Own investigations have shown that the clinical picture of this electrolyte disturbance is also characterized by impairments of ability to stand and marked clinical dehydration, with the latter seeming to play a key role in the pathogenesis of hyperkalemia. Based on these studies, the present project will address the therapeutic controllability of hyperkalemia and aims to identify the underlying mechanisms that are involved in the restoration of potassium homeostasis. A secondary aim of this project is to close knowledge gaps with respect to the pathogenesis and clinical relevance of hyperkalemia in neonatal calves with diarrhea.