Searching for the novel signalling molecule in vascular abnormal contraction

寻找血管异常收缩的新型信号分子

• 批准号: 15K18970
• 负责人: ZHANG Ying
• 金额: $ 2.58万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K18970/
• 关键词: 血管攣縮; paxillin; Fyn; Rho-kinase; 血管病; 血管平滑筋; 異常収縮; 分子間相互作用; Ｆｙｎ

项目成果

Fyn-mediated tyrosine phosphorylation of a novel signaling molecule, paxillin controls stress fiber formation and migration of cancer cells

Fyn 介导的新型信号分子酪氨酸磷酸化，桩蛋白控制癌细胞的应激纤维形成和迁移

• 发表时间: 2018
• 作者: Shiori Yokobayashi;Ying Zhang;Takafumi Okamoto;Tomoka Morita;Hiroko Kishi;Takeshi Yamamoto;Sei Kobayashi1
• 通讯作者: Sei Kobayashi1

The involvement of membrane rafts in the signal transduction of abnormal vascular smooth muscle contraction mediated by SPC/Fyn/ROK pathway

膜筏参与SPC/Fyn/ROK通路介导的异常血管平滑肌收缩的信号转导

• 发表时间: 2017
• 作者: Hiroko Kishi;Ying Zhang;Katsuko Kajiya;Tomoka Morita;Bochao Lyu;Min Zhang;Xiaoyan Li;Sei Kobayashi
• 通讯作者: Sei Kobayashi

SPC/Fyn/Rhoキナーゼシグナル伝達経路の阻害剤

SPC/Fyn/Rho 激酶信号通路抑制剂

• 发表时间: 2015

The involvement of membrane rafts in the signal transduction of abnormal vascular smooth muscle contraction mediated by SPC/Fyn/ROK pathway: Part II

膜筏参与SPC/Fyn/ROK通路介导的异常血管平滑肌收缩的信号转导：第二部分

• 发表时间: 2018
• 作者: Hiroko Kishi;Miki Kajima;Katsuko Kajiya;Ying Zhang;Tomoka Morita;Bochao Lyu;Min Zhang;Sei Kobayashi
• 通讯作者: Sei Kobayashi

Paxillin as a novel signaling molecule regulates actin stress fiber formation and migration of vascular smooth muscle cells by its N-terminus binding to the active Fyn

Paxillin 作为一种新型信号分子，通过其 N 末端与活性 Fyn 结合来调节肌动蛋白应激纤维的形成和血管平滑肌细胞的迁移

• 发表时间: 2017
• 作者: Ying Zhang;Hiroko Kishi;Katsuko Kajiya;Tomoka Morita;Sei Kobayashi.
• 通讯作者: Sei Kobayashi.