Functional analysis of CNOT3 in mice devoid of CNOT3 in T cell specific manner

CNOT3 在缺乏 CNOT3 的小鼠中以 T 细胞特异性方式进行的功能分析

• 批准号: 15K19140
• 负责人: Kureha Taku
• 金额: $ 2.33万
• 依托单位: Okinawa Institute of Science and Technology Graduate University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K19140/
• 关键词: T細胞分化; 正の選択; 脱アデニル化; CCR4-NOT複合体; TCRシグナル; CCR4-NOT; deadenylation; positive selection

项目成果

Poly(A) shortening of ASK1 mRNA contributes to positive selection of thymocytes through impairment of TCR-induceed stress response

ASK1 mRNA 的 Poly(A) 缩短通过损害 TCR 诱导的应激反应来促进胸腺细胞的正选择

• 发表时间: 2016
• 作者: Taku Ito-Kureha;Taishin Akiyama;Masahiro Morita;Tadashi Yamamoto
• 通讯作者: Tadashi Yamamoto

CNOT3 is important for thymocyte development through the regulation of TCR-mediated cell death signaling.

CNOT3 通过调节 TCR 介导的细胞死亡信号对胸腺细胞发育非常重要。

• 发表时间: 2015
• 作者: Taku Ito-Kureha;Taishin Akiyama;Masahiro Morita;Hidenori Ichijo;Tadashi Yamamoto
• 通讯作者: Tadashi Yamamoto

The CCR4-NOT complex subunit CNOT3, is required for T cell maturation through dampening TCR-induced stress response.

CCR4-NOT 复合亚基 CNOT3 是 T 细胞通过抑制 TCR 诱导的应激反应而成熟所必需的。

• 发表时间: 2015
• 作者: Taku Ito-Kureha;Taishin Akiyama;Masahiro Morita;Tadashi Yamamoto
• 通讯作者: Tadashi Yamamoto

Poly(A) shortening of ASK1 mRNA contributes to positive selection of thymocytes through impairment of TCR-induced stress response

ASK1 mRNA 的 Poly(A) 缩短通过损害 TCR 诱导的应激反应来促进胸腺细胞的正选择

• 发表时间: 2016
• 作者: Taku Ito-Kureha;Taishin Akiyama;Masahiro Morita;Tadashi Yamamoto
• 通讯作者: Tadashi Yamamoto