Programmable Aperture for Resistive Sensing of Nanoparticles

用于纳米粒子电阻传感的可编程孔径

• 批准号: 505646011
• 负责人: Professor Dr. Andreas Dietzel
• 金额: --
• 依托单位: Université de Picardie Jules Verne (UPJV)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/505646011?language=en
• 关键词: Programmable; Aperture; Resistive; Sensing; Nanoparticles

Applications of nanoparticles are numerous, from scratch resistance coatings and electronic components to nano-medicine therapies. For instance, lipid nanoparticles are of special interest for encapsulating poorly water-soluble active ingredients and are now a key component of COVID-19 mRNA vaccines. To ensure the reliability of products and the efficacy and safety of therapies, methods for controlling the quality of nanoparticles are of great importance. PARS project aims at developing a resistive-based measurement method based on a programmable aperture, which partially is defined by an elastomeric material, whose shape is locally deformed by wirelessly controlled bistable microactuators. They will be activated by shape memory alloy (SMA) elements, that can be optically adressed by laser beams, through wavelength selective waveguides, thereby controlling their independent stable states. The choice of optical power supply and control has been made to avoid disturbances of fast resistive pulse signals with low magnitude before amplification. Finally, the resistive measurement of particles with the help of the aperture in the form of a pore with digitally controlled local cross-sections and multiple microelectrodes will be demonstrated in a microfluidic setup. The multiple signals obtained from different pore positions will provide fingerprints that will allow conclusions not only about the size but also the morphology of the individual particles and the compositions of heterogeneous particle populations. Based on this concept, sorting of small particles based on size and morphology and integration with microfluidic nanoparticle production and impedance measurements that indicate also dielectric particle properties will also be considered in the longer term.

纳米颗粒的应用范围非常广泛，从耐刮擦涂层和电子元件到纳米药物治疗。例如，脂质纳米颗粒对于封装水溶性差的活性成分特别感兴趣，并且现在是COVID-19 mRNA疫苗的关键组分。为了确保产品的可靠性以及治疗的有效性和安全性，控制纳米颗粒质量的方法非常重要。PARS项目旨在开发一种基于可编程孔径的连续测量方法，该孔径部分由弹性体材料定义，其形状通过无线控制的微致动器局部变形。它们将被形状记忆合金（SMA）元件激活，该形状记忆合金（SMA）元件可以通过波长选择波导被激光束光学寻址，从而控制它们的独立稳定状态。光电源和控制的选择已作出，以避免干扰的快速电阻脉冲信号与低幅度放大前。最后，在微流体装置中，将演示在具有数字控制的局部横截面和多个微电极的孔的形式的孔的帮助下的颗粒的电阻测量。从不同孔位置获得的多个信号将提供指纹，其将允许不仅关于单个颗粒的大小而且关于其形态和异质颗粒群体的组成的结论。基于这一概念，基于尺寸和形态的小颗粒分选以及与微流体纳米颗粒生产和阻抗测量的整合也将在更长的时间内被考虑，阻抗测量也指示介电颗粒特性。