DLS feedback controlled continuous particle production

来自布伦瑞克工业大学微技术研究所（IMT）的可控微流控纳米颗粒发生器与美因茨弗劳恩霍夫微工程与微系统研究所（IMM）开发的流动dls装置相结合，形成了一个反馈控制的纳米颗粒反应器，能够在长期稳定的过程中精确调节颗粒的大小、大小分布和形状。该项目基于IMT在制药应用芯片实验室系统方面多年的经验。在“micropart”中，在特定控制条件下进行的微系统中的粒子生成是一个中心主题。到目前为止，只有在单独的系统中制备后，才能通过测量和计数来验证所需的粒子特性。flowDLS原型允许在流动中测量颗粒。在这个项目中，该设备将与一个微流控颗粒生成单元相结合，创建一个用户友好的系统，用于集成分析的纳米颗粒生产。设想的系统结合了大学水平开发的方法和弗劳恩霍夫研究所的综合分析外围。它将进一步发展到工业实验室可用的水平。应用合作伙伴ConSenxus GmbH是一家在颗粒分析方法领域拥有数十年经验的设备制造商。目标系统的特殊魅力在于其灵活性，因为整体概念包括各个模块。可以连接到系统上的微流体或测量小管保持可互换。这意味着分析部分以后可以与进一步的颗粒生产系统结合使用。“共识”拥有有用的联系和必要的专门知识，可以使该系统适应潜在用户的需要。该设备使用户无需进行内部分析，无需进行少量颗粒生产。因此，它扩大了可能的用户群体，降低了运营商的成本和总体工作量。这是因为该设备的操作不需要经过专门培训的人员。待开发的系统可以很容易地通过泵连接到初级材料的供应，在调整适当的参数后，按一下按钮就可以开始连续的颗粒生产，并进行连续的性能监测。其目的不仅是为了满足用户的直接需求，而且是为了开辟新的研究课题。例如，预计具有可控特性参数的纳米制剂的可用性在样品中只有很小的差异，这将允许对各自的生物效应进行详细的研究。

The combination of a controllable microfluidic nanoparticle generator from the Institute of Microtechnology (IMT), TU Braunschweig, with the flowDLS device developed at the Fraunhofer Institute for Microengineering and Microsystems (IMM) in Mainz results in a feedback controlled nanoparticle reactor, which is capable to precisely adjust the particle size, size distribution, and shape of the particles in a long-term stable process. The project is based on many years of experince with lab-on-chip systems for pharmaceutical applications at the IMT. Already in the FOR "Mikropart", particle generation in microsystems carried out under particularly controlled conditions was a central topic. So far, the required verification of particle properties by measurement and counting is only possible after the preparation in a separate system. The flowDLS prototype allows a particle measurement in flow. Within this project, the device will be combined with a microfluidic particle generation unit to create a user-friendly system for nanoparticle production with integrated analytics. The envisaged system combines methods developed on university level with integrated analytical periphery of the Fraunhofer Institute. It will be be further developed up to the level of usability in industrial laboratories. The application partner ConSenxus GmbH is a device manufacturer with decades of experience in the field of particle analysis methods. The special charm of the targeted system is found in its flexibility, as the overall concept includes individual modules. A microfluidic or measuring cuvette that can be attached to the system remains interchangeable. This means that the analytical part can later be used in combination with further particle production systems. ConSenxus has useful contacts and the necessary special knowledge to adapt the system to the needs of potential users. The device spares users, stepping into particle production in very small quantities, the need for in-house analytics. It thus expands the possible user group and reduces costs and overall effort for the operator. This is due to the fact that no specially trained personnel is required for the operation of the device. The system to be deveoped can be easily connected to the supply of primary materials via pumps and after adjusting the appropriate parameters, continuous particle production with continuous property monitoring starts at the push of a button. The aim is not only to satisfy direct user requirements, but also to open up new research topics. For example, it is expected that the availability of nanoformulations with controllable property parameters featuring only small variances in a sample will allow detailed investigations on the respective biological effects.