Basal forebrain mediated modulation of information processing in olfactory cortical areas in awake behaving mice
基底前脑介导的清醒行为小鼠嗅觉皮层区域信息处理的调节
基本信息
- 批准号:506373013
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Units
- 财政年份:
- 资助国家:德国
- 起止时间:
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Sensory information uptake and processing are some of the central tasks of the brain. Sensory input is shuttled through several relay stations that all heavily process and modulate this information to adapt it to the animal's needs. State-dependent adaptations can be mediated by so-called classical neuromodulatory centres like the basal forebrain (BF) or locus coeruleus that innervate many different brain areas along the sensory pathways. The BF is a particularly interesting brain area since its influence on e.g. sensory gain modulation or the sharpening of receptive fields can profoundly influence behavioural as well as cognitive processes. Newer studies suggest that state-dependent adaptations are probably due to a complex interplay of modulatory processes at different cortical and subcortical processing levels. In the olfactory system, research on BF neuromodulation has been focused mainly at the level of the olfactory bulb (OB), the first stage of central olfactory information processing while modulation in higher olfactory cortical areas has been largely ignored, probably due to a lack of detailed knowledge of BF to olfactory cortex connection characteristics as well as accessibility of these deep brain areas.Here, we propose a detailed investigation of BF influence on the two most anterior olfactory cortical regions, the anterior olfactory nucleus (AON) and the anterior piriform cortex (APC). These cortical olfactory areas seem to be of special importance since they do not only receive strong olfactory sensory input as well as centrifugal projections from neuromodulatory centres but they also send numerous projections back to the OB. First, we will investigate the centrifugal BF to AON/APC connectivity using dual-colour circuit tracing, asking which BF neuronal subtypes and subnuclei are predominantly projecting to the olfactory cortex and if BF neurons projecting to AON and APC form separate or overlapping populations. Furthermore, we will use this tracing approach to specifically activate AON or APC projecting BF neurons using optogenetic actuators while recording olfactory cortical neuronal activity in both anesthetized as well as awake behaving mice. In the second set of experiments, we will ask how specific activation or inhibition of BF fibres in AON or APC affects olfactory behaviour.
感觉信息的吸收和处理是大脑的一些核心任务。感官输入通过几个中继站来回传递,这些中继站都对这些信息进行大量处理和调整,使其适应动物的需要。状态依赖性适应可以由所谓的经典神经调节中心介导,如基底前脑(BF)或蓝斑,它们沿感觉通路支配许多不同的大脑区域。BF是一个特别有趣的大脑区域,因为它对感觉增益调节或感受野锐化的影响可以深刻地影响行为和认知过程。较新的研究表明,状态依赖性适应可能是由于不同皮层和皮层下加工水平的调节过程的复杂相互作用。在嗅觉系统中,BF神经调节的研究主要集中在嗅球(OB)水平,OB是中枢嗅觉信息处理的第一阶段,而在很大程度上忽视了高嗅皮质区的调节,这可能是由于缺乏对BF与嗅皮质连接特征的详细了解以及这些脑深部区域的可及性。在这里,我们提出了一个详细的研究BF对两个最前部的嗅觉皮质区域,前嗅核(AON)和前梨状皮质(APC)的影响。这些皮质嗅觉区域似乎特别重要,因为它们不仅接收强烈的嗅觉感官输入以及来自神经调节中心的离心投影,而且还将大量投影发送回OB。首先,我们将使用双色电路追踪来研究离心BF到AON/APC的连接。询问哪些BF神经元亚型和亚核主要投射到嗅觉皮层,以及投射到AON和APC的BF神经元是否形成单独或重叠的种群。此外,我们将使用这种追踪方法,使用光致动器特异性激活AON或APC投射BF神经元,同时记录麻醉和清醒行为小鼠的嗅觉皮质神经元活动。在第二组实验中,我们将询问AON或APC中BF纤维的特定激活或抑制如何影响嗅觉行为。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Professor Dr. Markus Rothermel其他文献
Professor Dr. Markus Rothermel的其他文献
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{{ truncateString('Professor Dr. Markus Rothermel', 18)}}的其他基金
Top-down (State dependent) Modulation of Sensory Processing in the Mouse Olfactory Bulb
小鼠嗅球感觉处理的自上而下(状态相关)调节
- 批准号:
250583768 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Independent Junior Research Groups
Modulation of sensory processing in the rodent olfactory system
啮齿动物嗅觉系统感觉处理的调节
- 批准号:
170743528 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Research Fellowships
Olfactory-limbic connection: from scents to behavior
嗅觉与边缘系统的联系:从气味到行为
- 批准号:
445965029 - 财政年份:
- 资助金额:
-- - 项目类别:
Research Grants
Role of cortico-subcortical loops in olfactory stimulus detection and figure background separation
皮质-皮质下环路在嗅觉刺激检测和图形背景分离中的作用
- 批准号:
520287065 - 财政年份:
- 资助金额:
-- - 项目类别:
Priority Programmes
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