Photoinduced regio- and enantio-selective C-N coupling of unactivated secondary alkyl halides

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The aim of this project is the synthesis of a library of chemically and biologically highly important amino-acid type molecules in a regio- and enantioselective fashion. Novel synthesis method(s) are to be developed in order to construct such structures using light and appropriate ligands. For this purpose, a copper-catalyzed cleavage of usually challenging secondary carbon-halogen bond is to be performed regioselectively, where the regioselectivity between the inherently favored primary carbon-halogen and the challenging secondary carbon-halogen center will be tuned to favor the secondary carbon-halogen center either under a Curtin-Hammett type scenario or by using a directing group. Computational calculations are to be performed in order to gain a very detailed insight into the reaction mechanism. We expect the synthesized compounds will not only be useful for biological studies, but will also serve as a potential ligand library in the field of catalysis to develop new transformations.