Photoinduced regio- and enantio-selective C-N coupling of unactivated secondary alkyl halides

该项目的目的是以区域和对映选择性的方式合成化学和生物学上高度重要的氨基酸类型分子的库。为了使用光和适当的配体构建这样的结构，将开发新的合成方法。为此目的，通常具有挑战性的仲碳-卤素键的铜催化裂解将区域选择性地进行，其中固有有利的伯碳-卤素和具有挑战性的仲碳-卤素中心之间的区域选择性将被调整为在Curtin-Hammett型情形下或通过使用导向基团有利于仲碳-卤素中心。为了获得对反应机理的非常详细的了解，将进行计算计算。我们期望合成的化合物不仅可用于生物学研究，而且还将作为催化领域的潜在配体库，以开发新的转化。

The aim of this project is the synthesis of a library of chemically and biologically highly important amino-acid type molecules in a regio- and enantioselective fashion. Novel synthesis method(s) are to be developed in order to construct such structures using light and appropriate ligands. For this purpose, a copper-catalyzed cleavage of usually challenging secondary carbon-halogen bond is to be performed regioselectively, where the regioselectivity between the inherently favored primary carbon-halogen and the challenging secondary carbon-halogen center will be tuned to favor the secondary carbon-halogen center either under a Curtin-Hammett type scenario or by using a directing group. Computational calculations are to be performed in order to gain a very detailed insight into the reaction mechanism. We expect the synthesized compounds will not only be useful for biological studies, but will also serve as a potential ligand library in the field of catalysis to develop new transformations.