Multi-Bond-Forming Processes: Step-Economical Synthesis In Batch And Flow

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This project aims to develop better ways to make and understand organic substances: the materials that make up all known life forms, our medicines, and many designed materials. Based on the previous development of powerful multi-bond-forming processes, the purpose of this project is to develop cascade sequences involving dendralenes in new and innovative ways. The project plans to generalise these processes and apply them in short total syntheses; extend the boundaries of multi-bond-forming processes and break new records; and reach higher levels of synthetic efficiency and selectivity by introducing the latest flow chemistry and automated reaction optimisation technology.