Multi-Bond-Forming Processes: Step-Economical Synthesis In Batch And Flow

多重键形成工艺：批量和流程中的步骤经济合成

• 批准号: DP160104322
• 负责人: Prof Michael Sherburn
• 金额: $ 57.39万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104322
• 关键词: Multi; Bond; Forming; Processes; Step

This project aims to develop better ways to make and understand organic substances: the materials that make up all known life forms, our medicines, and many designed materials. Based on the previous development of powerful multi-bond-forming processes, the purpose of this project is to develop cascade sequences involving dendralenes in new and innovative ways. The project plans to generalise these processes and apply them in short total syntheses; extend the boundaries of multi-bond-forming processes and break new records; and reach higher levels of synthetic efficiency and selectivity by introducing the latest flow chemistry and automated reaction optimisation technology.

该项目旨在开发更好的方法来制造和理解有机物质：构成所有已知生命形式的材料，我们的药物和许多设计材料。基于以前开发的强大的多键形成过程，该项目的目的是以新的和创新的方式开发涉及dendralene的级联序列。该项目计划推广这些工艺并将其应用于短时间全合成;扩展多键形成工艺的边界并打破新记录;并通过引入最新的流动化学和自动反应优化技术来达到更高水平的合成效率和选择性。