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Secretion mechanism of pathogenic proteases and adhesions in the periodontal pathogen Porphyromonas gingivalis.

Secretion mechanism of pathogenic proteases and adhesions in the periodontal pathogen Porphyromonas gingivalis.
牙周病原菌牙龈卟啉单胞菌致病蛋白酶的分泌机制和粘连。
批准号:
20249073
负责人:
NAKAYAMA Koji
金额:
$31.03万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Porphyromonas gingivalis secretes strong proteases called gingipains that are implicated in periodontal pathogenesis. Comparative genome analysis and genetic experiments revealed proteins involved in gingipain secretion. These proteins were similar in sequence to Flavobacterium johnsoniae gliding motility proteins. Disruption of the F. johnsoniae porT ortholog resulted in defects in motility and chitinase secretion, providing a link between a unique protein translocation system and a motility apparatus in members of the Bacteroidetes phylum.
期刊论文(45)
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科研奖励(0)
会议论文
比較ゲノム解析から発見されたグラム陰性細菌の新規タンパク分泌機構
通过比较基因组分析发现革兰氏阴性菌的新蛋白质分泌机制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kaneda M, Zhang D, Bhattacharjee R, Nakahama KI, Arii S, Morita I., 中山浩次]
通讯作者: 中山浩次
DOI: 10.1186/1471-2180-9-105
发表时间: 2009-05-26
期刊: BMC microbiology
影响因子: 4.2
作者: [Kuboniwa M, Amano A, Hashino E, Yamamoto Y, Inaba H, Hamada N, Nakayama K, Tribble GD, Lamont RJ, Shizukuishi S]
通讯作者: Shizukuishi S
Neutralization of Toxic Heme by Porphyromonas gingivalis Hemoglobin Receptor.
牙龈卟啉单胞菌血红蛋白受体中和有毒血红素。
DOI: --
发表时间: 2010
期刊: J Biochem.
影响因子: --
作者: [N.T.Nhien, N.T.Huy, M.Naito, T.Oida, D.T.Uyen, M.Huang, M.Kikuchi, S.Harada, K.Nakayama, K.Hirayama, K.Kamei.]
通讯作者: K.Kamei.
Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis.
非铁金属卟啉对牙龈卟啉单胞菌生长和基因表达的影响。
DOI: --
发表时间: 2011
期刊: Microb.Immunol.
影响因子: --
作者: [Yukitake, H., M.Yoshimura]
通讯作者: M.Yoshimura
31
    Elucidation of feedback regulation of the expression of the type IX secretion system (T9SS) of Porphyromonas gingivalis
    • 批准号:
      20K09921
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2020
    • 负责人:
      NAKAYAMA Koji
    • 依托单位:
    Formation model of Bacteroidia bacteria pilus-X-ray crystal structure analysis and molecular reconstruction experiment-
    • 批准号:
      16H05504
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.98万
    • 财政年份:
      2016
    • 负责人:
      NAKAYAMA Koji
    • 依托单位:
    Elucidation of cascade regulation by two different control systems of the type IX secretion system
    • 批准号:
      16K15776
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.16万
    • 财政年份:
      2016
    • 负责人:
      NAKAYAMA Koji
    • 依托单位:
    Biogenesis of sugar moiety of anionic lipopolysaccharide associated with CTD proteins
    • 批准号:
      26670804
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2014
    • 负责人:
      NAKAYAMA Koji
    • 依托单位:
    海外基金