Mechanism of adrenocortical differentiation by exchange and conversion of enhancers
Mechanism of adrenocortical differentiation by exchange and conversion of enhancers
批准号:
21249018
负责人:
MOROHASHI Ken-ichirou
金额:
$21.8万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Ad4BP/SF-1, a member of nuclear receptor superfamily, plays pivotal role in differentiation and function of the adrenal cortex through regulating various target genes. It has been hypothesized that active enhancers should be exchanged or selected through conversion of chromatin structure when Ad4BP/SF-1 functions during the tissue development. In the present study, we performed ChIP-sequence analyses of theDNA recovered with antibodies for Ad4BP/SF-1 and modified histones. As the consequence, it was found that Ad4BP/SF-1 regulates glycolytic gene expression through binding to enhancers localized in and around the genes.
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The fetal and adult adrenal cortex
胎儿和成人的肾上腺皮质
DOI:
--
发表时间:
2011
期刊:
Mol. Cell. Endocrinol.
影响因子:
--
作者:
[FUJIOKA, Hiromichi, et al., K. Morohashi and M. Zubair.]
通讯作者:
K. Morohashi and M. Zubair.
Tissue-specific Enhancers of Ad4BP/SF-1
Ad4BP/SF-1 的组织特异性增强子
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[K. Morohashi]
通讯作者:
K. Morohashi
生殖腺の発生と性分化メカニズム
性腺发育和性别分化机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[土肥寿文, 北泰行, 他, Miyata M., 諸橋憲一郎]
通讯作者:
諸橋憲一郎
ダイオキシン受容体(AhR)の生殖腺における機能 : 性ステロイドホルモンの合成
二恶英受体(AhR)在性腺中的功能:性类固醇激素的合成
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[馬場崇, 三村純正, 嶋雄一, 中村直人, 大脇亜希子, 大島基彦, 原田信広, 山本雅之, 藤井義明, 諸橋憲一郎]
通讯作者:
諸橋憲一郎
Milwaukee
密尔沃基
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Lineage of Testicular Leydig cells and Adrenal Cortex. K. Morohashi, Z. Mohamad, T. Baba, K. Miyabayashi, H. Otake, Y. Shima]
通讯作者:
Y. Shima
共 46 条
Mechanism of differentiation of fetal Leydig cells by active and suppressive types of nuclear receptors
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批准号:16H05142
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.23万
-
财政年份:2016
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负责人:MOROHASHI Ken-ichirou
-
依托单位:
Mechanism of adrenocortical development
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批准号:18390091
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.77万
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财政年份:2006
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负责人:MOROHASHI Ken-ichirou
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依托单位:
Elucidation of gene cascade regulating sex differentiation
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批准号:16086214
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$168.96万
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财政年份:2004
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负责人:MOROHASHI Ken-ichirou
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依托单位:
Molecular Mechanisms of Gonadal Sex Differentiation
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批准号:14370332
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.9万
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财政年份:2002
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负责人:MOROHASHI Ken-ichirou
-
依托单位:
Estimation of effects of endocrine disruptor
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批准号:11557078
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.7万
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财政年份:1999
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负责人:MOROHASHI Ken-ichirou
-
依托单位:
Mechanism of sex differentiation in gonad and brain
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批准号:11307001
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$26.18万
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财政年份:1999
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负责人:MOROHASHI Ken-ichirou
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依托单位:
Elucidation of the mechanism of sex differentiation and its application to effective reproduction of animal resources
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批准号:09558097
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.74万
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财政年份:1997
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负责人:MOROHASHI Ken-ichirou
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依托单位:
Function of Ad4BP in the process of gonadal sex differentiation
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批准号:08680745
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.54万
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财政年份:1996
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负责人:MOROHASHI Ken-ichirou
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依托单位:
海外基金