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Mechanism of adrenocortical differentiation by exchange and conversion of enhancers

Mechanism of adrenocortical differentiation by exchange and conversion of enhancers
增强子交换和转化导致肾上腺皮质分化的机制
批准号:
21249018
负责人:
MOROHASHI Ken-ichirou
金额:
$21.8万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Ad4BP/SF-1, a member of nuclear receptor superfamily, plays pivotal role in differentiation and function of the adrenal cortex through regulating various target genes. It has been hypothesized that active enhancers should be exchanged or selected through conversion of chromatin structure when Ad4BP/SF-1 functions during the tissue development. In the present study, we performed ChIP-sequence analyses of theDNA recovered with antibodies for Ad4BP/SF-1 and modified histones. As the consequence, it was found that Ad4BP/SF-1 regulates glycolytic gene expression through binding to enhancers localized in and around the genes.
期刊论文(58)
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会议论文
The fetal and adult adrenal cortex
胎儿和成人的肾上腺皮质
DOI: --
发表时间: 2011
期刊: Mol. Cell. Endocrinol.
影响因子: --
作者: [FUJIOKA, Hiromichi, et al., K. Morohashi and M. Zubair.]
通讯作者: K. Morohashi and M. Zubair.
Tissue-specific Enhancers of Ad4BP/SF-1
Ad4BP/SF-1 的组织特异性增强子
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [K. Morohashi]
通讯作者: K. Morohashi
生殖腺の発生と性分化メカニズム
性腺发育和性别分化机制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [土肥寿文, 北泰行, 他, Miyata M., 諸橋憲一郎]
通讯作者: 諸橋憲一郎
ダイオキシン受容体(AhR)の生殖腺における機能 : 性ステロイドホルモンの合成
二恶英受体(AhR)在性腺中的功能:性类固醇激素的合成
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [馬場崇, 三村純正, 嶋雄一, 中村直人, 大脇亜希子, 大島基彦, 原田信広, 山本雅之, 藤井義明, 諸橋憲一郎]
通讯作者: 諸橋憲一郎
46
    Mechanism of differentiation of fetal Leydig cells by active and suppressive types of nuclear receptors
    • 批准号:
      16H05142
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.23万
    • 财政年份:
      2016
    • 负责人:
      MOROHASHI Ken-ichirou
    • 依托单位:
    Mechanism of adrenocortical development
    Elucidation of gene cascade regulating sex differentiation
    Molecular Mechanisms of Gonadal Sex Differentiation
    • 批准号:
      14370332
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.9万
    • 财政年份:
      2002
    • 负责人:
      MOROHASHI Ken-ichirou
    • 依托单位:
    海外基金