Development of drug delivery system for central nervous system

本研究旨在开发治疗中枢神经系统疾病的新型脑间质给药系统。最近，我们使用对流增强递送(CED)进行了基础和临床研究。对流增强输送(CED)是一种将各种分子输送到中枢神经系统的局部输注技术。我们首先开发了实时MRI引导监测系统。在该系统中，我们将化疗药物ACNU和Gd-DTPA的混合物注入MRI进行实时监测。随后，我们开发了预测Gd-DTPA在非人灵长类动物脑干中分布的计算模拟系统。此外，我们还开发了一种新型的药物输送装置。

This study aimed at developing novel brain interstitial drug delivery system for the treatment of central nervous system disorders. Recently we performed basic and clinical study using convection-enhanced delivery (CED). Convection-enhanced delivery (CED) is a local infusion technique that delivers various molecules to the central nervous system. We firstdeveloped real-time MRI guided monitoring system. In this system, we infuse the mixture of chemotherapeutic agent; ACNU with Gd-DTPA for real-time monitoring using MRI. Subsequently, we developed computational simulating system that predicts the distribution of Gd-DTPA in a brainstem of non-human primate. In addition, we developed a novel drug delivery apparatus.