Comprehensive study on research and development of circulatory assist systems for bettering therapeutic outcome of severe heart failure pediatric patients

我们开发了几种类型的下一代儿科循环支持系统。具有长期耐用性和优良的抗血栓性能的心肺支持系统可以提供安全的长期心肺支持，有望成为高死亡率传染病大流行的最终治疗选择。我们还进行了三种不同类型的人工心脏的研究和开发：1)NCVC型气动准心脏辅助装置，2)婴幼儿植入式轴流辅助装置，3)超紧凑的带流体轴承的可植入轴流辅助装置。所有系统都取得了显著的进展，分别达到了：1)一年内的药物应用阶段，2)产品设计阶段，3)临床前测试阶段。我们的研究和开发活动将继续和加快，以期尽快应用于临床。

We developed several types of next-generation pediatric circulatory support systems. The cardiopulmonary support system with long-term durability and superior antithrombotic property can provide safe long-term cardiopulmonary support, and is expected as ultimate therapeutic option for the possible pandemic of high mortality infectious diseases. We also proceeded research and development of three different types of artificial hearts: 1) NCVC type pneumatic paracorporeal pediatric ventricular assist device, 2) implantable axial flow ventricular assist device for infants, and 3) ultra-compact implantable axial flow pediatric ventricular assist device with hydrodynamic bearings. All systems have significantly progressed and came to: 1) pharmaceutical application within 1 year, 2) product design phase, and 3) preclicnical test phase, respectively. Our research and development activity will be continued and accelerated, aiming at earliest clinical application.