Studies of pathological involvement of Sox9 in osteoarthritis and discovery of new treatment for osteoarthritis

关节软骨细胞过表达Sox9可延缓骨性关节炎的发生。此外，使用基因芯片对来自小鼠关节软骨细胞、Sox9-EGFP小鼠和Sox9-EGFP缺失嵌合体的全基因组筛选发现，一个基因与骨关节炎有关，一个基因由Sox9诱导。此外，用Sox9-EGFP软骨细胞对约10000种化学试剂进行筛选，发现有7种化学试剂具有Sox9指示活性。

Overexpression of Sox9 in articular chondrocytes resulted in delay of osteoarthritis change. In addition, genome-wide screening using GeneChip with chondrocytes derived mouse articular cartialge, Sox9-EGFP mice, and Sox9-EGFP null chimera identified one gene involved in osteoarthritis and one gene induced by Sox9. Furthermore, screening of about 10000 chemical reagents using Sox9-EGFP chondrocytes revealed 7 chemical reagents which has Sox9-indecing activity.