Experimental research on the pathogenesis and pathophysiology of diseases that cause dementia

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Accumulation of abnormal proteins in the brain, which is referred to as proteinopathy, is the essential feature of neurodegenerative diseases that cause dementia. Dissolution of the abnormal protein accumulation is a promising strategy to overcome such dementia disorders as Alzheimer's disease and frontotemporal lobar degeneration. The aim of this study is to investigate into the proteinopathy overlap, a yet unsolved issue in this field. We have analyzed immunohistochemically the postmortem brain tissues of neurodegenerative diseases from a view point of proteinopathy overlap. We also have made mouse models that carry at least two factors so that the models recapitulate aspects of the overlap.