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A study of bone atrophy treatment by detection of factors in osteocytes involved in mechanical stress

A study of bone atrophy treatment by detection of factors in osteocytes involved in mechanical stress
检测骨细胞机械应力相关因子治疗骨萎缩的研究
批准号：
23659717
负责人：
AKIYAMA Haruhiko
金额：
$2.33万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659717/
关键词：
骨細胞メカノセンサーイオンチャネル廃用性骨萎縮遺伝子改変マウスマイクロアレイ

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中文摘要
翻译
使用废骨骨细胞进行全基因组筛选显示BK通道基因上调。RT-PCR结果显示，骨细胞表达KCNMB1、2和4亚基基因。构建CaK-GFP转基因小鼠，再构建Col1a1-mRFP1；制备了CaK-GFP双半转基因小鼠。当使用BK通道开启剂或阻滞剂时，我们正在尝试使用共聚焦显微镜对这些小鼠的成骨细胞和成骨细胞进行实时成像。
英文摘要
Genome-wide screening using osteocytes in disused bone showed upregulation of BK channel genes. RT-PCR revealed that osteocytes express KCNMB1, 2 and 4 subunit genes. CaK-GFP transgenic mice were generated, and then Col1a1-mRFP1; CaK-GFP double hemi-transgenic mice were produced. We are trying live imaging of osteoblasts and osteclasts in these mice using confocal microscope when BK channel opener or blocker reagents are administered.
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会议论文
Pathological study of abnormal protein accumulation and its propagation in the brain of patients with dementia
Studies of pathological involvement of Sox9 in osteoarthritis and discovery of new treatment for osteoarthritis
  • 批准号：
    21249078
  • 项目类别：
    Grant-in-Aid for Scientific Research (A)
  • 资助金额：
    $30.53万
  • 财政年份：
    2009
  • 负责人：
    AKIYAMA Haruhiko
  • 依托单位：
    Kyoto University
Experimental research on the pathogenesis and pathophysiology of diseases that cause dementia
Basic analysis and clinical usage of a bone-specific secreted protein, HA4
  • 批准号：
    18390413
  • 项目类别：
    Grant-in-Aid for Scientific Research (B)
  • 资助金额：
    $11.11万
  • 财政年份：
    2006
  • 负责人：
    AKIYAMA Haruhiko
  • 依托单位：
    Kyoto University
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