Liver producing hormones and life style related diseases

研究了肝脏产生激素（称为肝细胞因子）对生活方式疾病（如糖尿病）的影响。 硒蛋白P是我们实验室在Cell Metabolism 2010上发表的第一个肝细胞因子。硒蛋白P诱导与脂肪和肌肉组织协调的胰岛素抵抗（分别发表在Pros One 2012和2014）。二甲双胍治疗降低了硒蛋白的表达（J Biol Chem 2014）。 新发现了另一种肝细胞因子，白细胞来源的趋化因子2（Diabetes 2014）。

Influence of liver producing hormones, termed as hepatokine, on life style diseases such as diabetes were studied. Selenoprotein P was published as the first hepatokine in Cell Metabolism 2010 from our laboratory. Selenoprotein P induces insulin resistance coordinated with adipose and muscle tissues (published in Pros One 2012, and 2014, respectively). Expression of Selenoprotein was decreased by the treatment of metformin (J Biol Chem 2014). Another hepatokine, leukocyte cell-derived chemotaxin 2, was newly identified (Diabetes 2014).