Liver producing hormones and life style related diseases

肝脏产生激素和生活方式相关疾病

• 批准号: 23249042
• 负责人: KANEKO Shuichi
• 金额: $ 30.95万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-05-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23249042/
• 关键词: ゲノム; 発現制御; 肝臓; 栄養; 生活習慣病

Influence of liver producing hormones, termed as hepatokine, on life style diseases such as diabetes were studied. Selenoprotein P was published as the first hepatokine in Cell Metabolism 2010 from our laboratory. Selenoprotein P induces insulin resistance coordinated with adipose and muscle tissues (published in Pros One 2012, and 2014, respectively). Expression of Selenoprotein was decreased by the treatment of metformin (J Biol Chem 2014). Another hepatokine, leukocyte cell-derived chemotaxin 2, was newly identified (Diabetes 2014).

研究了肝脏产生激素（称为肝细胞因子）对生活方式疾病（如糖尿病）的影响。 硒蛋白P是我们实验室在Cell Metabolism 2010上发表的第一个肝细胞因子。硒蛋白P诱导与脂肪和肌肉组织协调的胰岛素抵抗（分别发表在Pros One 2012和2014）。二甲双胍治疗降低了硒蛋白的表达（J Biol Chem 2014）。 新发现了另一种肝细胞因子，白细胞来源的趋化因子2（Diabetes 2014）。

项目成果

金沢大学附属病院内科（旧第一内科）恒常性制御学講座

金泽大学医院（原第一内科）内科体内平衡科

金沢大学医学部付属病院内科(旧第一内科)恒常性制御学講座

金泽大学医院体内平衡科内科（原第一内科）

Pharmacokinetics and pharmacodynamics of insulin aspart in patients with Type 2 diabetes : Assessment using a meal tolerance test under clinical conditions

门冬胰岛素在 2 型糖尿病患者中的药代动力学和药效学：在临床条件下使用膳食耐受试验进行评估

• DOI: 10.1111/j.1440-1681.2012.05708.x
• 发表时间: 2012
• 期刊: Clin Exp Pharmacol Physiol
• 作者: H Ando;S Kurita;A Shimizu;K Kato;K Ishikura;K Taji;M Uno;Y Takeshita;H Misu;A Fujimura;S Kaneko;T Takamura
• 通讯作者: T Takamura

Adipose Tissue-Derived Stem Cells as a Regenerative Therapy for a Mouse Steatohepatitis-Induced Cirrhosis Model

• DOI: 10.1002/hep.26470
• 发表时间: 2013-09-01
• 期刊: HEPATOLOGY
• 影响因子: 13.5
• 作者: Seki, Akihiro;Sakai, Yoshio;Kaneko, Shuichi
• 通讯作者: Kaneko, Shuichi

LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance

• DOI: 10.2337/db13-0728
• 发表时间: 2014-05-01
• 期刊: DIABETES
• 影响因子: 7.7
• 作者: Lan, Fei;Misu, Hirofumi;Takamura, Toshinari
• 通讯作者: Takamura, Toshinari