Liver producing hormones and life style related diseases

研究了肝脏产生激素（称为肝因子）对生活方式疾病（如糖尿病）的影响。硒蛋白P作为首个肝因子发表于2010年《细胞代谢》杂志。硒蛋白P诱导与脂肪和肌肉组织协调的胰岛素抵抗（分别发表于Pros One 2012和2014）。硒蛋白的表达在二甲双胍处理下降低（J Biol Chem 2014）。另一种肝因子，白细胞来源的趋化素2，是新发现的（Diabetes 2014）。

Influence of liver producing hormones, termed as hepatokine, on life style diseases such as diabetes were studied. Selenoprotein P was published as the first hepatokine in Cell Metabolism 2010 from our laboratory. Selenoprotein P induces insulin resistance coordinated with adipose and muscle tissues (published in Pros One 2012, and 2014, respectively). Expression of Selenoprotein was decreased by the treatment of metformin (J Biol Chem 2014). Another hepatokine, leukocyte cell-derived chemotaxin 2, was newly identified (Diabetes 2014).