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Disturbance of hepatic function and over nutrition-related diseases

Disturbance of hepatic function and over nutrition-related diseases
肝功能障碍和过度营养相关疾病
批准号:
18109008
负责人:
KANEKO Shuichi
金额:
$64.4万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2010

项目摘要

项目成果

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中文摘要
翻译
肝脏摄取各种营养物质,代谢葡萄糖、蛋白质、脂质和药物,并通过血流全身递送代谢物。我们已经证明,营养相关的疾病,如动脉粥样硬化,糖尿病,癌症和炎症,部分是由肝脏功能障碍引起的,肝脏摄取过量的营养物质。建立了肝脏相关疾病的概念,为肝脏疾病的诊断和治疗提供了基础资料。
英文摘要
Liver uptakes varieties of nutrients, metabolizes glucose, proteins, lipids, and drugs and systemically delivers the metabolites through blood streams. We have demonstrated that nutrition related diseases such as atherosclerosis, diabetes, cancer, and inflammation are partially caused by the dysfunction of liver which uptakes excess nutrients. We established the concept of the liver related diseases, and showed the fundamental findings for the development of the diagnosis and therapy for the diseased liver.
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DOI: 10.1007/s00125-008-1194-6
发表时间: 2009-02-01
期刊: DIABETOLOGIA
影响因子: 8.2
作者: [Ando, H., Takamura, T., Kaneko, S.]
通讯作者: Kaneko, S.
DOI: 10.1002/hep.21203
发表时间: 2006-06-01
期刊: HEPATOLOGY
影响因子: 13.5
作者: [Mizukoshi, Eishiro, Nakamoto, Yasunari, Kaneko, Shuichi]
通讯作者: Kaneko, Shuichi
Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis
慢性肝炎治疗中肝小叶和汇管区细胞的差异干扰素信号传导
DOI: --
发表时间: 2010
期刊: C.J Hepatol 53(5)
影响因子: --
作者: [M Honda, M Nakamura, M Tateno, A Sakai, T Shimakami, T Shirasaki, T Yamashita, K Arai, T Yamashita, Y Sakai, S Kaneko.]
通讯作者: S Kaneko.
CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes.
2 型糖尿病患者的 CD14 单核细胞在 ER 应激下很脆弱且功能受损。
DOI: --
发表时间: 2010
期刊: Diabetes 59(3)
影响因子: --
作者: [T Komura, Y Sakai, M Honda, T Takamura, K Matsushima, S Kaneko.]
通讯作者: S Kaneko.
87
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