Alteration of stress response by a histone methylation abnormality in hematopoietic stem cells

造血干细胞中组蛋白甲基化异常改变应激反应

• 批准号: 26860729
• 负责人: KAWAHARA MASAHIRO
• 金额: $ 2.41万
• 依托单位: Shiga University of Medical Science (2015)Kyoto University (2014)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26860729/
• 关键词: 造血分化; ヒストンメチル化; 白血病; 造血幹細胞; ヒストン脱メチル化酵素; 血球分化; DNA損傷ストレス

项目成果

Hypomethylation of the Treg-Specific Demethylated Region in FOXP3 Is a Hallmark of the Regulatory T-cell Subtype in Adult T-cell Leukemia

• DOI: 10.1158/2326-6066.cir-15-0148
• 发表时间: 2015-12
• 期刊: Cancer Immunology Research
• 影响因子: 10.1
• 作者: Yayoi Shimazu;Y. Shimazu;M. Hishizawa;M. Hamaguchi;Y. Nagai;N. Sugino;Sumie Fujii;M. Kawahara;N. Kadowaki;H. Nishikawa;S. Sakaguchi;A. Takaori-Kondo

Generation of engraftable leukemic stem cells from iPS cells derived from a secondary AML patient

利用源自继发性 AML 患者的 iPS 细胞生成可移植白血病干细胞

• 发表时间: 2015
• 作者: Kazuhisa Chonabayashi;Masahiro Kawahara;Masatoshi Nishizawa;Akifumi Takaori-Kondo;Shinya Yamanaka;and Yoshinori Yoshida
• 通讯作者: and Yoshinori Yoshida

iPS technology revealed the genetic and functional diversity present in a single MDS patient.

iPS 技术揭示了单个 MDS 患者的遗传和功能多样性。

• 发表时间: 2014
• 作者: Kazuhisa Chonabayashi;Masahiro Kawahara;Akira Watanabe;Naoki Amano;Keisuke Okita;Masatoshi Nishizawa;Norimitsu Kadowaki;Akifumi Takaori-Kondo;Shinya Yamanaka;Yoshinori Yoshida.
• 通讯作者: Yoshinori Yoshida.

Co-occurrence of monoclonal gammopathy and myelodysplasia: a retrospective study of fourteen cases.

单克隆丙种球蛋白病和骨髓增生异常的共存：十四例病例的回顾性研究。

• DOI: 10.1007/s12185-014-1570-6
• 发表时间: 2014
• 期刊: Int J Hematol
• 影响因子: 2.1
• 作者: 1.Yoshida Y;Oguma S;Ohno H;Nakabo Y;Katsurada T;Kawahara M;Kawabata H.
• 通讯作者: Kawabata H.

LSD1 regulates myeloid differentiation via affecting the enhancer activity of GFI1

LSD1 通过影响 GFI1 增强子活性调节骨髓分化

• 发表时间: 2015
• 作者: Noriko Sugino;Masahiro Kawahara;Akinori Kanai;Hirotaka Matsui;Goichi Tatsumi;Ryusuke Yamamoto;Yuya Nagai;Sumie Fujii;Yayoi Shimazu;Masakatsu Hishizawa;Toshiya Inaba;Takayoshi Suzuki;and Akifumi Takaori-Kondo
• 通讯作者: and Akifumi Takaori-Kondo