Creation of Soft & Wet Artificial Muscles and Their Application as Biomotion Systems

软体创作

• 批准号: 14GS0301
• 负责人: OSADA Yoshihito
• 金额: $ 439.3万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Creative Scientific Research
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14GS0301/
• 关键词: Actuator; Tough gel; Artificial muscle; Double network; Artificial cartilage; Low friction; Bio-compatibility; Soft machine; DNゲル; 高分子ゲル; ソフト&ウェットマター; ナノバイオマシン; ソフト&ウェットアクチュエータ; 超高強度; 超低摩擦; 超高強度超低摩擦ゲル; 生体適合性; コンプレックス形成

(I) Synthesis of hydrogel as soft and wet artificial musclesBy introducing the double network structure into hydrogel, we succeeded in obtaining the hydrogel with extra-ordinary high mechanical toughness (Fracture strength of about several Mpa).In addition, by changing the inhomogeous structure of the first network from several 10nm to micrometer, we succeeded in controlling the mechanical behavior of the DN gel from brittle-like to ductile-like. The ductile-like DN gel exhibits an elongation as high as 20 times before failure. To apply this gel as artificial cartilage, we further introduced the graft structure to the DN gel surface and succeeded in obtaining the gel with a fracture stress of several 10MPa, fracture energy of 1000 J/cm^2, and sliding friction coefficient of 10^<-5>〜10^<-4>.(II) Application of hydrogel as substitutes of bio-organsTo apply the gel with excellent mechanical properties as artificial cartilage, wear property, bio-durability and biocompatibility were investigated. Several kinds of DN gels sustained cyclic pin-on-flat test for one million times with a total sliding distance of 50 km, and showed a wearing rate of 10^<-8>-10^<-7>mm^3/Nm. This wear resistance is higher than that of the high density polyethylene (wearing rate of 10^<-7>mm^3/Nm).Implantation test of DN gel in the rabbits showed that among several kinds of DN gels, the PAMPS/PDMAAm DN gel was the most suitable for bio-durability. Moreover, it was found that the gel showed a good biocompatibility when artificial cartilage made of PAMPS/PDMAAm was implanted in the articular joints of rabbits.Furthermore, we discovered that normal cartilage was regenerated in situ when the PAMPS/PDMAA gel was imbedded into the articular joint several mm from the surface as artificial cartilage. This great discovery will lead to a completely new method to repair the damaged cartilage in situ.

（i）将水凝胶作为柔软和湿的人造肌肉的合成，将双网络结构引入水凝胶中，我们成功地获得了具有非凡高机械韧性的水凝胶（大约几个MPA的断裂强度），通过将第一个网络从几个10NM转换为微米的不合理结构，从微米中转变为固定型号，我们可以从微米中转变为良好的行为。类似延性的。延性的DN凝胶在失败前表现出高达20倍的伸长率。为了将这种凝胶作为人造软骨，我们进一步将移植结构引入了DN凝胶表面，并成功地获得了几个10MPA的断裂应力，1000 J/cm^2的断裂能量，并在10^<-5> 〜10^<-4>。（ii）型号的extol offortial gylogel As-bio as-aS-aS-aforgan As-bio aS-aS-aS-aforgan a iS-bio aS-aS-aS-aS-aS-aS-aforgan均应施加的滑动摩擦系数中研究了人造软骨，磨损特性，生物耐用性和生物相容性。几种DN凝胶进行了循环插条测试一百万次，总滑动距离为50 km，并且磨损速度为10^<-8> -10^<-7> mm^3/nm。这种耐磨性高于高密度聚乙烯的耐磨性（磨损的速度为10^<-7> mm^3/nm）。兔子中DN凝胶的植入测试表明，在几种DN凝胶中，PAMPS/PAMPS/PDMAAM DN凝胶最适合生物耐用性。此外，发现凝胶在兔子的关节中植入了pamp/pdmaam制成的人造软骨时表现出良好的生物相容性。当时，我们发现，当小型/pdmaa凝胶被置入了几个mm的液压卡车中时，我们发现正常软骨是在现场再生的正常软骨。这一伟大的发现将导致一种全新的方法来修复原位损坏的软骨。

项目成果

Effects of local administration of vascular endothelial growth factor on properties of the in situ frozen-thawed anterior cruciate ligament in rabbits

• DOI: 10.1177/0363546505278700
• 发表时间: 2006-01-01
• 期刊: AMERICAN JOURNAL OF SPORTS MEDICINE
• 影响因子: 4.8
• 作者: Ju, YJ;Tohyama, H;Yasuda, K
• 通讯作者: Yasuda, K

Gel machines constructed from chemically cross-linked actins and myosins

• DOI: 10.1002/1521-4095(20020816)14:16<1124::aid-adma1124>3.0.co;2-m
• 发表时间: 2002-08-16
• 期刊: ADVANCED MATERIALS
• 影响因子: 29.4
• 作者: Kakugo, A;Sugimoto, S;Osada, Y
• 通讯作者: Osada, Y

A LONG-TERM FOLLOW-UP OF SILICONE-RUBBER INTERPOSITION ARTHROPLASTY FOR OSTEOARTHRITIS OF THE THUMB CARPOMETACARPAL JOINT

• DOI: 10.1142/s0218810405002607
• 发表时间: 2005-07-01
• 期刊: JOURNAL OF HAND SURGERY-ASIAN-PACIFIC VOLUME
• 影响因子: 0.5
• 作者: Minami, Akio;Iwasaki, Norimasa;Yasuda, Kazunori
• 通讯作者: Yasuda, Kazunori

Observation of stiff domain structure on collagen gels by wide-range scanning probe microscopy

• DOI: 10.1143/jjap.45.2353
• 发表时间: 2006-03-01
• 期刊: JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS
• 作者: Mizutani, T;Haga, H;Kawabata, K
• 通讯作者: Kawabata, K

INTELLIGENT GELS

• DOI: 10.1038/scientificamerican0593-82
• 发表时间: 1993-05-01
• 期刊: SCIENTIFIC AMERICAN
• 影响因子: 3
• 作者: OSADA, Y;ROSSMURPHY, SB
• 通讯作者: ROSSMURPHY, SB