Dynamic Bonds and Mechanical Properties of Tough Hydrogels: Medical Device and Gel Electrolyte Applications
坚韧水凝胶的动态键和机械性能:医疗器械和凝胶电解质应用
基本信息
- 批准号:RGPIN-2019-04952
- 负责人:
- 金额:$ 2.04万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2021
- 资助国家:加拿大
- 起止时间:2021-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
BACKGROUND. Dynamic bonds, physical or chemical bonds that can be released by external stimuli in a reversible way, are the most fundamental building block for smart soft materials. While individual dynamic bond may be considered as weak, tough hydrogels (fracture energies of ~10,000 J/m2) has been realized by clustering hydrogen bonds or ionic pairs, which also enables reversible adhesion and self-healing. Despite of the technological importance and empirical successes, current understanding on the correlation between these dynamic bond clusters and the mechanical properties of tough hydrogels at its infancy. This problem is partly because of limited capability of existing experimental tools. SOLUTION. Overall objective of PROGRAM 1 is to establish microchannel cantilever sensor, whose vibration being monitored by laser Doppler vibrometer, as a standard tool for studying the dynamic bonds in (hydro)gels. Established for ultrasensitive detection in biosensing, the two additional merits of the method are picoliter sample size and the variety of vibration modes. The short-term objective (3 years) is to validate the microchannel cantilever technology as a tool for quantitative microrheology. In mid- to long-term plan (5 years and beyond), collaborations with polymer chemists, density functional theory experts, and mechanics theoretician will make quantitative correlations between the characteristics of dynamic bonds (such as individual/clustered bond strength and association/dissociation kinetics) and dynamic mechanical properties (time-resolved evolution of complex moduli). APPPLICATION. With a purpose to complement my current research programs on biomedical devices and battery gel electrolytes, PROGRAM 2 is on molecular design of sticky hydrogels with tunable adhesion. The short- to mid-term objective (5 years) is to fabricate hemorrhage suppressing gel pad that can apply quickly and then release on demand. Long-term objective (beyond 5 years) is to integrate wound-dressing or implantable bioelectronics on the sticky hydrogel platform for advanced healthcare devices, which will be realized by converging my whole research activities. IMPACT. Fundamental understanding on dynamic bonds and its impact to mechanical properties is tremendous across all disciplines of soft materials. Molecular design of sticky and tough hydrogels can be translated to traditional technologies such as rubbers, adhesives, and coatings, as well as to emerging technological areas of biomedical devices, drug delivery, and soft robotics. The proposed DG complements my entire research program to become a self-consistent unity with strong scientific foundation. HQPs trained in my unique and highly interdisciplinary research program will have qualities required for engineers in future society, where convergence between disciplines is the key. Scientific/technological discovery and trained HQPs from the proposed DG will evolve academia and industry in Canada and in the world.
背景动态键,可以通过外部刺激以可逆的方式释放的物理或化学键,是智能软材料最基本的构建块。虽然单个动态键可能被认为是弱的,但通过聚集氢键或离子对已经实现了坚韧的水凝胶(断裂能为~ 10,000 J/m2),这也能够实现可逆的粘附和自愈合。尽管技术的重要性和经验的成功,目前的理解这些动态键簇和坚韧水凝胶的机械性能之间的相关性处于起步阶段。这个问题部分是因为现有的实验工具的能力有限。溶液本论文的总体目标是建立微通道悬臂梁传感器,并利用激光多普勒测振仪监测其振动,作为研究(水)凝胶中动态键的标准工具。该方法的两个额外优点是皮升的样品大小和振动模式的多样性。短期目标(3年)是验证微通道悬臂梁技术作为定量微流变学的工具。在中长期计划(5年及以后)中,与聚合物化学家,密度泛函理论专家和力学理论家的合作将在动态键的特性(如单个/簇键强度和缔合/解离动力学)和动态力学性能(复杂模量的时间分辨演变)之间建立定量关联。 为了补充我目前在生物医学设备和电池凝胶电解质方面的研究计划,我的第二个研究课题是粘性水凝胶的分子设计。短期至中期目标(5年)是制造可快速应用然后按需释放的出血抑制凝胶垫。长期目标(超过5年)是将伤口敷料或植入式生物电子学集成到粘性水凝胶平台上,用于先进的医疗器械,这将通过整合我的整个研究活动来实现。冲击在软材料的所有学科中,对动态键及其对机械性能的影响的基本理解是巨大的。粘性和坚韧水凝胶的分子设计可以转化为传统技术,如橡胶,粘合剂和涂料,以及生物医学设备,药物输送和软机器人等新兴技术领域。拟议的DG补充了我的整个研究计划,成为一个具有强大科学基础的自洽统一体。在我独特的和高度跨学科的研究计划中训练的HQP将具有未来社会中工程师所需的素质,其中学科之间的融合是关键。科学/技术发现和来自拟议总干事的训练有素的HQP将推动加拿大和世界的学术界和工业界的发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Chung, HyunJoong其他文献
Chung, HyunJoong的其他文献
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{{ truncateString('Chung, HyunJoong', 18)}}的其他基金
Dynamic Bonds and Mechanical Properties of Tough Hydrogels: Medical Device and Gel Electrolyte Applications
坚韧水凝胶的动态键和机械性能:医疗器械和凝胶电解质应用
- 批准号:
RGPIN-2019-04952 - 财政年份:2022
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Dynamic Bonds and Mechanical Properties of Tough Hydrogels: Medical Device and Gel Electrolyte Applications
坚韧水凝胶的动态键和机械性能:医疗器械和凝胶电解质应用
- 批准号:
RGPIN-2019-04952 - 财政年份:2020
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Dynamic Bonds and Mechanical Properties of Tough Hydrogels: Medical Device and Gel Electrolyte Applications
坚韧水凝胶的动态键和机械性能:医疗器械和凝胶电解质应用
- 批准号:
RGPIN-2019-04952 - 财政年份:2019
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Materials, Device, And Interface Engineering for Non-Conventional Electronics by Hard/Soft Material Integration
通过硬/软材料集成实现非常规电子产品的材料、器件和接口工程
- 批准号:
435914-2013 - 财政年份:2018
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Towards clothing-like neural sensing and stimulation: thin, but robust, wearable electronics
迈向类似衣服的神经传感和刺激:薄而坚固的可穿戴电子产品
- 批准号:
521315-2017 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
Engage Grants Program
Materials, Device, And Interface Engineering for Non-Conventional Electronics by Hard/Soft Material Integration
通过硬/软材料集成实现非常规电子产品的材料、器件和接口工程
- 批准号:
435914-2013 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Materials, Device, And Interface Engineering for Non-Conventional Electronics by Hard/Soft Material Integration
通过硬/软材料集成实现非常规电子产品的材料、器件和接口工程
- 批准号:
435914-2013 - 财政年份:2016
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Improving longevity of printed electronics by failure analysis of conductive and piezoresistive inks
通过导电和压阻油墨的故障分析来提高印刷电子产品的使用寿命
- 批准号:
501862-2016 - 财政年份:2016
- 资助金额:
$ 2.04万 - 项目类别:
Engage Grants Program
Materials, Device, And Interface Engineering for Non-Conventional Electronics by Hard/Soft Material Integration
通过硬/软材料集成实现非常规电子产品的材料、器件和接口工程
- 批准号:
435914-2013 - 财政年份:2015
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Skin Adhesive Smart Patch to Monitor Hydration Status in Real-Time
实时监测水合状态的皮肤粘合智能贴片
- 批准号:
478519-2015 - 财政年份:2015
- 资助金额:
$ 2.04万 - 项目类别:
Collaborative Health Research Projects
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