Biomedical Application of Gas Biology through Multidisciplinary Approaches

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The multiplicity of gas actions and gas targets and the difficulty in measuring local gas concentrations obscures detailed mechanisms whereby gases exert their actions, and many questions remain unanswered. In this project, advanced mass spectrometry combined with high-performance computer technology allowed us to mine biological mechanisms for gas-responsive signal transducing systems. We also take an integrated approach to the interaction of gases by considering the physiological significance of CO, NO, and H2S on metabolic systems and energy-supporting enzyme systems including cytochrome c oxidase, a key target and central mediator of mitochondrial respiration. By evaluating gas-mediated control functions from both in vitro and in vivo perspectives, we attempted to elaborate on the complex multiple interactions of O(2), NO, CO, and H2S