Physiological function of hydrogen sulfide in osteoblasts.
Physiological function of hydrogen sulfide in osteoblasts.
批准号:
24659686
负责人:
NAKAMURA Takashi
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
Hydrogen sulfide has been recognized as a gaseous mediator with a variety of physiological functions. However, its role in the control of skeletal function is unknown. Hydrogen sulfide can be physiologically generated by enzymes, cystathionine beta-synthase (CBS). To define the physiological function of hydrogen sulfide in the skeletal tissue, we performed functional analysis of bone metabolism in CBS knockout mice. The knockout mice showed significant growth retardation and various skeletal disorders. These results suggest that hydrogen sulfide is essential for normal bone metabolism.
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慶應義塾大学医学部・医化学教室
庆应义塾大学医学院医学化学系
DOI:
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影响因子:
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作者:
[]
通讯作者:
慶應義塾大学医学部医化学教室
庆应义塾大学医学院医学化学系
DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
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DOI:
10.1073/pnas.1117560109
发表时间:
2012-03-13
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Hirose, Yoshikazu, Saijou, Eiko, Miyajima, Atsushi]
通讯作者:
Miyajima, Atsushi
エストロゲン受容体ノックアウトマウスを用いた研究の発展
使用雌激素受体基因敲除小鼠的研究进展
DOI:
--
发表时间:
2013
期刊:
O.li.v.e.-骨代謝と生活習慣病の連関-
影响因子:
--
作者:
[加藤茂明, 中村貴]
通讯作者:
中村貴
慶應義塾大学医学部医化学教
庆应义塾大学医学院医学化学教授
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 7 条
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