Studies on environmental carcinogenesis in People's Republic of China.

中华人民共和国环境致癌研究。

• 批准号: 63042004
• 负责人: AOKI Kunio
• 金额: $ 10.3万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Overseas Scientific Survey.
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63042004/
• 关键词: Epidemiological Study of Stomach Cancer; Epidemiological Study of Lung Cancer; Campylobacter Pylori Infection; Serum Beta-carotene; Screening of Lung Cancer

1 . Stomach cancer (1) Salted pork, dried salted small fishes and vinagered noodle showed strong mutasgenieity. (2) Improving dietary habit in a high risk area, China, is associated with improving stomach mucosa in the high risk area. (3)The correlaton between campylobacter infection stomach cancer is now under study. (4) Regressive changes of cappillary of blood vessel in chronic inflammation of submucosa were found. (5) Resected tissues of stomach could be cultured out of body the specimens are under study. (6) New monoclonal antibody GLO13 is useful for diagnosis in China. (7) Positive association of changes in frequency of Green-yellow vegetable and changes in serum carotene for one year was observed. (8) Four thousands inhabitants measured serum beta -carotene in Japan are following up. (9) About 100 cases with chronic gastritis are treated by traditional herbs medicine in China. (10)A new method of methylen blue could be clarified extent and degree of intestinalisation of gastric mucosa in Japan. Intake of fruits inhibited progression of gastric intestinalisation. Meat intake promoted proliferation of parietal cells of stomach.2 . Lung Cancer (1) Age at onset of lung cancer was younger Shenyang than in Kyoto. Squamous cell carcinoma for the younger age groups less than 39 was frequently observed in Japan and small cell carcinoma was in China. Adeno-cystic carcinoma was frequently found in Chinese lung cancer. Mass screening using sputum and chest indirect radiography showed a relatively high prevalence of lung cancer in Fusin, China. DNA quantitative diagnosis on cytologin specinems is now under study. (2) Case-control study on lung cancer was carried out the data of 100 cases and 200 controls were now under study.

1 .胃癌（1）咸猪肉、咸小鱼干、腌面有较强的致突变性。(2)在中国的高风险地区，改善饮食习惯与改善高风险地区的胃粘膜有关。（3）弯曲杆菌感染与胃癌的关系正在研究中。(4)胃粘膜下层慢性炎症时，毛细血管呈退行性改变。（5）胃切除组织可体外培养，标本正在研究中。(6)新的单克隆抗体GLO 13可用于中国的诊断。(7)青黄色蔬菜的频率变化与血清胡萝卜素的变化呈正相关。(8)在日本，有4000名居民测量了血清中的β-胡萝卜素，他们正在跟踪调查. (9)我国用中药治疗慢性胃炎约100例。(10)A新的亚甲蓝法可以阐明日本胃粘膜钙化的范围和程度。水果的摄入抑制了胃粘膜化的进展。肉类摄入促进胃壁细胞增殖.肺癌（1）沈阳市肺癌发病年龄较京都市年轻。鳞状细胞癌常见于日本39岁以下的年轻人群，而小细胞癌常见于中国。腺囊性癌是中国人肺癌中的常见癌。采用痰液和胸部间接X线检查进行的大规模筛查显示，中国阜新地区肺癌的患病率相对较高。细胞学标本的DNA定量诊断正在研究中。(2)本文对100例肺癌病例和200例对照进行了病例对照研究。