Environmental regulation of opsin expression and spectral tuning in the vertebrate retina

脊椎动物视网膜视蛋白表达和光谱调谐的环境调节

• 批准号: DP0451436
• 负责人: Prof Shaun Collin
• 金额: $ 14.62万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0451436
• 关键词: Environmental; regulation; opsin; expression; spectral

Exciting new evidence shows that the vertebrate visual system is extraordinarily plastic and that the colour and brightness of the ambient light regulates both the spatial and temporal expression of visual pigments (opsin) genes and the degree of spectral filtering in the retina. Based on findings that more than one visual pigment can be co-expressed in a single photoreceptor type, we plan to manipulate the light environment in order to identify and quantify the effect of different lighting regimes by morphological, spectral and molecular techniques in a concerted effort to understand the regulation of opsin expression.

令人兴奋的新证据表明，脊椎动物的视觉系统具有非凡的可塑性，环境光的颜色和亮度调节视色素（视蛋白）基因的空间和时间表达以及视网膜中光谱过滤的程度。基于一个以上的视觉色素可以共同表达在一个单一的感光细胞类型的研究结果，我们计划操纵光环境，以确定和量化不同的照明制度的影响，通过形态学，光谱和分子技术，共同努力，以了解视蛋白表达的调节。