Further Genetic and Molecular studies of an Important Prokaryotic Regulator Protein TyrR.

基因组编码许多功能，其表达随特定细胞环境的不同而显著不同。被称为调节蛋白的特殊蛋白质充当传感器，探测环境中的细微变化，并作为回应，影响某些基因的表达，要么抑制它们，要么刺激它们的活动。我们正在与简单细菌大肠杆菌的TyrR调节蛋白合作，以阐明在这些控制中使用的分子策略。由于这种蛋白质控制着许多具有不同功能的基因的表达，进化选择了同样不同的机制来实现适当的转录反应。对大肠杆菌基因组和由TyrR调控的各种基因的详细了解使其成为此类基础研究的极佳系统。

Genomes encode many functions whose expression varies dramatically depending on particular cellular environments. Special proteins called Regulator Proteins act as sensors to detect subtle changes in the environment and, in response, to influence the expression of certain genes either dampening them down or stimulating their activity. We are working with the TyrR regulator protein of the simple bacterium Escherichia coli to elucidate the molecular strategies used in these controls. Because this protein controls the expression of a number of genes with diverse functions, evolution has selected equally diverse mechanisms to achieve appropriate transcriptional responses. The detailed knowledge of the E.coli genome and of the various genes regulated by TyrR make it an excellent system for such fundamental studies.