LIPID AND LIPOPROTEIN ADSORPTION AT BIOMATERIALS AND BIO-DIAGNOSTICS INTERFACES

生物材料和生物诊断界面上的脂质和脂蛋白吸附

• 批准号: DP0453099
• 负责人: Prof Hans Griesser
• 金额: $ 15.67万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0453099
• 关键词: LIPID; LIPOPROTEIN; ADSORPTION; BIOMATERIALS; BIO

This project aims to investigate molecular mechanisms involved in the formation of undesired biological deposits on synthetic materials and thereby help establish the scientific basis for the rational design of materials with improved compatibility with biological fluids and the engineering of a new generation of biomedical implant devices and bio-diagnostic devices. It is well known that proteins accumulate on synthetic solid surfaces. This project proposes to investigate whether lipids and lipoproteins also play key roles in the initiation of biological adsorption processes. Combined with the study of the interfacial forces responsible, this information will guide the design of preventative strategies.

该项目旨在研究在合成材料上形成有害生物沉积物的分子机制，从而为合理设计与生物流体兼容性更好的材料以及设计新一代生物医学植入设备和生物诊断设备奠定科学基础。众所周知，蛋白质会聚集在合成的固体表面上。该项目建议调查脂类和脂蛋白是否也在启动生物吸附过程中发挥关键作用。结合对负责的界面力的研究，这些信息将指导预防策略的设计。