Combating fungal biofilm growth on surfaces

抑制表面真菌生物膜的生长

• 批准号: DP150101674
• 负责人: Prof Hans Griesser
• 金额: $ 24.36万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-03-17 至 2020-07-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150101674
• 关键词: Combating; fungal; biofilm; growth; surfaces

This project aims to establish a scientific basis for the design and development of thin coatings, for use on biomedical devices, that can resist the attachment of fungal cells and the ensuing formation of infectious fungal biofilms on their surfaces. Advancing mechanistic understanding of how physico-chemical properties of materials surfaces influence fungal attachment will enable rational development and optimisation of coating chemistries and structures. Tethered antifungal compounds will be added to polymer surfaces by controlled polymerisation methods to provide active deterrence; factors such as conformational flexibility will be studied to optimise coatings, which may will prevent life-threatening infections and reduce healthcare costs.

该项目旨在为生物医学设备上使用的薄涂层的设计和开发建立科学基础，这些薄涂层可以抵抗真菌细胞的附着以及随后在其表面上形成感染性真菌生物膜。推进材料表面的物理化学性质如何影响真菌附着的机械理解将使涂层化学和结构的合理开发和优化成为可能。将通过受控聚合方法将栓系抗真菌化合物添加到聚合物表面，以提供主动威慑;将研究构象灵活性等因素，以优化涂层，这可能会预防危及生命的感染并降低医疗成本。