Next-generation immunological analysis of a cohort of monozygotic twins discordant for Multiple Sclerosis diagnosis.

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The pathophysiology of multiple sclerosis (MS), an autoimmune disease of the central nervous system, is still not fully understood. In this study, we will make use of a unique cohort of monozygotic twins discordant for MS, to decipher MS-related immune alterations with a particular focus on the T-cell compartment. We will associate MS-related phenotypic immune alterations with genetic trait loci to elucidate the genotype/phenotype interplay, and we will analyze the T-cell receptor repertoire in MS versus healthy twins. Key results will be validated in an independent cohort of early MS patients.