Next-generation immunological analysis of a cohort of monozygotic twins discordant for Multiple Sclerosis diagnosis.

对多发性硬化症诊断不一致的同卵双胞胎队列进行下一代免疫学分析。

• 批准号: 515678129
• 负责人: Professorin Dr. Luisa Klotz
• 金额: --
• 依托单位: Klinik für Neurologie mit Institut für Translationale Neurologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/515678129?language=en
• 关键词: Next; generation; immunological; analysis; cohort

The pathophysiology of multiple sclerosis (MS), an autoimmune disease of the central nervous system, is still not fully understood. In this study, we will make use of a unique cohort of monozygotic twins discordant for MS, to decipher MS-related immune alterations with a particular focus on the T-cell compartment. We will associate MS-related phenotypic immune alterations with genetic trait loci to elucidate the genotype/phenotype interplay, and we will analyze the T-cell receptor repertoire in MS versus healthy twins. Key results will be validated in an independent cohort of early MS patients.

多发性硬化症（MS）是一种中枢神经系统自身免疫性疾病，其病理生理机制尚未完全清楚。在这项研究中，我们将利用一个独特的队列的单卵双胞胎不一致的MS，破译MS相关的免疫改变，特别是重点对T细胞区室。我们将MS相关的表型免疫改变与遗传性状基因座，以阐明基因型/表型的相互作用，我们将分析T细胞受体库MS与健康双胞胎。关键结果将在早期MS患者的独立队列中进行验证。