Suction pipette measurements of mammalian rod photoreceptor recovery following intense bleaching exposures

强烈漂白暴露后哺乳动物视杆光感受器恢复的吸管测量

• 批准号: DP0451192
• 负责人: Em/Prof Trevor Lamb
• 金额: $ 6.32万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0451192
• 关键词: Suction; pipette; measurements; mammalian; rod

The aim of this project is to discover the events and processes that prevent retinal photoreceptors from recovering instantaneously following the cessation of exposure to extremely bright illumination. Recordings will be made from single rod photoreceptors cells isolated from the mammalian retina. The work will uncover the relative roles of the 'photoproducts' created when rhodopsin absorbs light: e.g. intermediates such as metarhodopsin and opsin. The molecular knowledge obtained will help us to understand why it is that the visual system recovers so slowly after the eye has experienced very intense light.

该项目的目的是发现阻止视网膜光感受器在停止暴露于极亮照明后立即恢复的事件和过程。 记录将从分离自哺乳动物视网膜的单视杆光感受器细胞进行。 这项工作将揭示当视紫红质吸收光时产生的“光产物”的相对作用：例如，中间体如变视紫红质和视蛋白。 获得的分子知识将帮助我们理解为什么眼睛在经历过非常强烈的光线后视觉系统恢复得如此缓慢。