Pulmonary Aspergillus infection progression determined by alveolar macrophages as initial responders (A06)

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A06 we will investigate the earliest decision points in alveolar macrophages (AMs) upon encounter with the pathogenic fungus Aspergillus fumigatus and interrogate the impact of previous exposures to other pathogens that appear to decisively alter lung immune surveillance. A06 aims to pinpoint cellular and molecular determinants resulting in an effective control of A. fumigatus in the alveolar space environment either by close AM- alveolar epithelial cells interactions or through recruitment of other immune cells such as neutrophilic granulocytes, monocytes and dendritic cells.