Pulmonary Aspergillus infection progression determined by alveolar macrophages as initial responders (A06)

由肺泡巨噬细胞作为初始反应者确定的肺部曲霉菌感染进展（A06）

• 批准号: 516725815
• 金额: --
• 依托单位: Molekularbiologisch - Infektiologische Labore der Medizinischen Klinik II
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/516725815?language=en
• 关键词: Pulmonary; Aspergillus; infection; progression; determined

A06 we will investigate the earliest decision points in alveolar macrophages (AMs) upon encounter with the pathogenic fungus Aspergillus fumigatus and interrogate the impact of previous exposures to other pathogens that appear to decisively alter lung immune surveillance. A06 aims to pinpoint cellular and molecular determinants resulting in an effective control of A. fumigatus in the alveolar space environment either by close AM- alveolar epithelial cells interactions or through recruitment of other immune cells such as neutrophilic granulocytes, monocytes and dendritic cells.

A06我们将研究肺泡巨噬细胞（AM）在遇到致病真菌烟曲霉时的最早决策点，并询问先前暴露于其他病原体的影响，这些病原体似乎决定性地改变了肺部免疫监视。A06的目的是查明细胞和分子决定因素，导致有效控制A。通过AM-肺泡上皮细胞的密切相互作用或通过募集其他免疫细胞如嗜中性粒细胞、单核细胞和树突细胞，在肺泡空间环境中释放烟曲霉毒素。