Metabolic control of innate and adaptive immune responses to cutaneous Staphylococcus aureus infection (C02)

对皮肤金黄色葡萄球菌感染的先天性和适应性免疫反应的代谢控制（C02）

• 批准号: 516727184
• 金额: --
• 依托单位: Institut für Systemimmunologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/516727184?language=en
• 关键词: Metabolic; control; innate; adaptive; immune

C02 will investigate how the metabolic competition between immune cells of the host and Staphyloccocus aureus shapes local immunity and how glucose uptake mechanisms of innate and adaptive immune cells prevent the spreading of the pathogen to secondary infection sites. C02 hypothesises that the metabolic and epigenetic reprogramming of T cells and neutrophils is relevant for determining local immunity and systemic protection from S. aureus infections and aim to characterise decision points governing this reprogramming.

C02将研究宿主免疫细胞和金黄色葡萄球菌之间的代谢竞争如何塑造局部免疫，以及天然免疫细胞和获得性免疫细胞的葡萄糖摄取机制如何防止病原体传播到继发感染部位。二氧化碳假设T细胞和中性粒细胞的代谢和表观遗传重编程与确定局部免疫和系统对金黄色葡萄球菌感染的保护有关，并旨在描述管理这种重编程的决策点。