Generating broad and stable resistance to gemini- and nanoviruses

对双子病毒和纳米病毒产生广泛且稳定的抗性

• 批准号: DP0453273
• 负责人: Prof James Dale
• 金额: $ 20.89万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-02-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0453273
• 关键词: Generating; broad; stable; resistance; gemini

The ssDNA geminiviruses and nanoviruses are considered a major threat to crop production in the tropics and subtropics. There are currently no effective control strategies for these viruses. We have been developing a novel transgenic strategy for generating resistance to ssDNA viruses based on the activation of a suicide gene in the presence of the viral Rep protein. Importantly, we have demonstrated proof-of-principle using Tobacco yellow dwarf mastrevirus. In this project, we aim to further develop this strategy into a broad and stable mechanism for generating resistance to all known geminiviruses and nanoviruses.

ssDNA双生病毒和纳米病毒被认为是热带和亚热带作物生产的主要威胁。目前还没有针对这些病毒的有效控制策略。我们一直在开发一种新的转基因策略，用于产生对ssDNA病毒的抗性，该策略基于在病毒Rep蛋白存在下激活自杀基因。重要的是，我们已经证明了使用烟草黄矮肥大病毒的原理证明。在这个项目中，我们的目标是进一步发展这种策略，使其成为一种广泛而稳定的机制，用于产生对所有已知双生病毒和纳米病毒的抗性。