Sex in Dragons: The molecular basis of genetic and environmental sex determination

龙的性别：遗传和环境性别决定的分子基础

• 批准号: DP0449935
• 负责人: Prof Jennifer Graves
• 金额: $ 41.78万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0449935
• 关键词: Sex; Dragons; molecular; basis; genetic

How animals determine sex has been debated over decades. Particularly mysterious is that sex is determined by genes in some animals, and by temperature in others. We will study closely related dragon lizards which determine sex via genes (GSD) or temperature (TSD). We will use novel genetic, molecular and cytological aproaches to discover genes and chromosomes that control sex determination in the GSD species, and explore their homologues in the TSD species. We expect this study will provide new insights to mechanisms of sex determination in all vertebrates, and demonstrate how genes and the environment interact to control the process.

动物如何决定性别已经争论了几十年。特别神秘的是，在某些动物中，性别是由基因决定的，而在另一些动物中，性别是由温度决定的。我们将研究通过基因（GSD）或温度（TSD）决定性别的密切相关的龙蜥蜴。我们将使用新的遗传学，分子和细胞学的方法来发现基因和染色体控制性别决定的GSD物种，并探讨其同源物在TSD物种。我们希望这项研究将为所有脊椎动物的性别决定机制提供新的见解，并展示基因和环境如何相互作用来控制这一过程。