Sex determination in dragons: Genetics, epigenetics and environment

龙的性别决定：遗传学、表观遗传学和环境

• 批准号: DP170101147
• 负责人: Prof Arthur Georges
• 金额: $ 70.8万
• 依托单位: University of Canberra
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170101147
• 关键词: Sex; determination; dragons; Genetics; epigenetics

This project aims to discover the master sex-determining gene in a reptile, how that gene is differentially regulated in males and females and by temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex determination. In many reptiles, like mammals, chromosomes determine sex. In others, the temperature at which their eggs are incubated determines sex. This project will study how temperature reverses chromosomal sex determination in dragon lizards. This could show how climatic extremes affect the biology of climate sensitive reptiles, and understand their vulnerability to climate change.

该项目旨在发现爬行动物中主要的性别决定基因，该基因如何在雄性和雌性中以及通过温度进行差异调节，并确定遗传和环境性别决定之间转变的进化驱动因素。在许多爬行动物中，如哺乳动物，染色体决定性别。在其他情况下，孵化卵的温度决定了性别。该项目将研究温度如何逆转龙蜥蜴的染色体性别决定。这可以显示极端气候如何影响气候敏感爬行动物的生物学，并了解它们对气候变化的脆弱性。