Bacterial cell behaviour in micro/nano-confined environments

该项目旨在进一步了解海洋细菌生物膜形成和表面调节代谢反应的机制。我们将调整光敏聚合物的表面特性（如？模特？表面）和探测细菌对表面的反应，被动地使用微/纳米制造结构和原子力显微镜;主动地使用单细胞的光学操作。结果将有助于有关中央生物现象的基础知识-下至单细胞过程-以及有关模拟自然微生物过程的抗菌表面制造的应用知识，对生物医学实践，环境，民用，采矿和制造工业应用具有更大的影响。

The project aims to progress the understanding of the mechanisms of marine bacteria biofilm formation and surface-modulated metabolic response. We will adjust the surface characteristics of photopolymers (as ?model? surfaces) and probe the bacterial response to surfaces, passively with micro/nano-fabricated structures and Atomic Force Microscopy; and actively with optical manipulation of single cells. The results will contribute to the fundamental knowledge regarding central biological phenomena -down to single-cell processes- as well as on applied knowledge regarding the manufacturing of antimicrobial surfaces that mimic natural bactericide processes, with larger implications on biomedical practice, and environmental, civil, mining and manufacturing industrial applications.