Tissue K+ and Na+ distribution in renal interstitial disease assessed by 39K and 23Na MRI (C07*)

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In this project we will characterize the tissue electrolyte distribution in renal tubular dysfunction. We will therefore develop new MRI methodology to analyse tissue ion concentrations. Specifically, 23Na & 39K MRI will be applied to detect muscle Na+ & K+ shifts in aldosteronism. Furthermore, we will utilize combined morphological and 23Na imaging of the human kidneys to determine physiological Na+ variations. As tissue Na+ retention occurs in inflammation, we hypothesize that acute allograft rejection is characterized by tissue Na+ accumulation and can be detected by 23Na MRI. Besides, we will evaluate how SGLT-2 inhibitors influence the kidney Na+ and extrarenal Na+ & K+ concentrations in CKD and heart failure.