Tissue K+ and Na+ distribution in renal interstitial disease assessed by 39K and 23Na MRI (C07*)

通过 39K 和 23Na MRI 评估肾间质疾病的组织 K 和 Na 分布 (C07*)

• 批准号: 517500899
• 金额: --
• 依托单位: Medizinische Klinik 4 - Nephrologie und Hypertensiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/517500899?language=en
• 关键词: Tissue; K+; Na+; distribution; renal

In this project we will characterize the tissue electrolyte distribution in renal tubular dysfunction. We will therefore develop new MRI methodology to analyse tissue ion concentrations. Specifically, 23Na & 39K MRI will be applied to detect muscle Na+ & K+ shifts in aldosteronism. Furthermore, we will utilize combined morphological and 23Na imaging of the human kidneys to determine physiological Na+ variations. As tissue Na+ retention occurs in inflammation, we hypothesize that acute allograft rejection is characterized by tissue Na+ accumulation and can be detected by 23Na MRI. Besides, we will evaluate how SGLT-2 inhibitors influence the kidney Na+ and extrarenal Na+ & K+ concentrations in CKD and heart failure.

在这个项目中，我们将描述肾小管功能障碍的组织电解质分布。因此，我们将开发新的MRI方法来分析组织离子浓度。具体而言，23 Na和39 K MRI将用于检测醛固酮增多症中的肌肉Na+和K+变化。此外，我们将利用人体肾脏的形态学和23 Na成像相结合，以确定生理Na+变化。由于炎症中发生组织Na+潴留，我们假设急性同种异体移植排斥反应的特征是组织Na+积聚，并且可以通过23 Na MRI检测到。此外，我们将评估SGLT-2抑制剂如何影响CKD和心力衰竭患者的肾脏Na+和肾外Na+ & K+浓度。