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Changes in neuroactive substances in trigeminal motor nucleus after peripheral nerve injury

Changes in neuroactive substances in trigeminal motor nucleus after peripheral nerve injury
周围神经损伤后三叉神经运动核神经活性物质的变化
批准号:
08835023
负责人:
WADA Yo
金额:
$1.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1996
资助国家:
日本
项目状态:
已结题
起止时间:
1996 至 1997

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中文摘要
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英文摘要
The aim of this study was to examine the change in alpha and beta calcitonin gene related peptide mRNA expression in trigeminal motor nucleus following peripheral nerve injury. Rats received the transection of left masseteric nerve under deep anesthesia. After 1-56 postoperative days, the brainstem was dissected out for in situ hybridization. Trigeminal motor nucleus showed beta-CGRP mRNA expression constitutively and no alpha-CGRP mRNA.After transection of unilateral masseteric nerve, trigeminal motor nucleus express alpha-CGRP mRNA dramatically and continued high level at least 8 weeks after nerve injury. beta-CGRP mRNA showed small increase compared to alpha-CGRP mRNA.These data suggest that trigeminal motor nucleus showed differential expression of alpha-and beta-CGRP mRNA after peripheral nerve injury.
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会议论文
Fukuoka, T.et al: "Expression of beta-calcitonin gene-related peptide in axotomized rubrospinal neurons and the effect of brain derived neurotrophic factor" Brain Research. 767. 250-258 (1997)
Fukuoka,T.等人:“β-降钙素基因相关肽在轴突红核脊髓神经元中的表达以及脑源性神经营养因子的作用”大脑研究。
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Miki, K et al: "Calcitonin gene-related peptide increase in the rat spinal dorsal horn and dorsan column reatous followings peytend nerve injury" Neuroscience. 82. 1243-1252 (1998)
Miki, K 等人:“大鼠脊髓背角和背柱反应性追随神经损伤中降钙素基因相关肽增加”《神经科学》。
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Fukuoka,T et al: "Etpression of β-calcitonin geve-related peptiole in atotowized rubrospinal neurons and the effect of brain derived neurotropho factor" Brain Research. 767. 250-258 (1997)
Fukuoka,T 等人:“β-降钙素 geve 相关肽在原子化红核脊髓神经元中的表达以及脑源性神经营养因子的作用”《大脑研究》767. 250-258 (1997)。
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6
    国内基金
    海外基金
    降钙素基因相关肽(Calcitonin gene-related peptide, CGRP)对穴位敏化的调节及机制研究
    • 批准号:
      81873385
    • 项目类别:
      面上项目
    • 资助金额:
      59.0万元
    • 批准年份:
      2018
    • 负责人:
      乔海法
    • 依托单位: