Multi-Dimensional Interactions in Ensembled Molecular System

集成分子系统中的多维相互作用

• 批准号: 09045035
• 负责人: OKU Akira
• 金额: $ 2.5万
• 依托单位: Kyoto Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09045035/
• 关键词: Ensembled Molecular System; Intermolecular Interactions; Three-Dimensional Structural Analysis; Asymmetric Synthesis; High-Resolution Nuclear Magnetic Resonance Spectrometry; Asymmetric Catalyst; Functional Design; 高分解能核磁気共鳴

The elucidation of multi-dimensional interactions in ensembled molecular system is of significant importance for the molecular-level understanding of biological processes, for the functional design of advanced materials, and for the molecular design of pharmaceuticals and agrochemicals, In the present research project, we corroborated with the research group of Prof. Ackerman of Washington university (USA) to promote die extensive utilization of three-dimensional structural-analysis system recently introduced to our institute.Two seminars were held for the researchers of our institute on the theoretical and practical aspects of a high-field nuclear magnetic resonance (MR) spectrometry as well as high-resolution mass spectrometry. Six professors of our institute visited Washington university to corroborate on the following specific research projects : (1) development of a rationally designed asymmetric catalysts based on the multi-dimensional interactions of chiral molecules, (2) quantitative treatment of the relation between the solid-phase function of organic materials and their NMR spectra, and (3) molecular design of bioactive molecules based on die molecular-level understanding of the multi-dimensional interactions.

阐明分子系统中多维相互作用对生物过程的分子水平理解、先进材料的功能设计以及药物和农用化学品的分子设计具有重要意义。我们与美国华盛顿大学Ackerman教授课题组合作，将最近引进我院的三维结构分析系统推广到模具的广泛应用。为研究所的研究人员举办了两次关于高场核磁共振（MR）光谱和高分辨率质谱的理论和实践方面的研讨会。本所6位教授访问美国华盛顿大学，对以下具体研究项目进行了确证：(1)基于手性分子的多维相互作用，合理设计不对称催化剂；(2)定量处理有机材料固相函数与其核磁共振谱之间的关系；(3)基于对多维相互作用的分子水平理解，设计生物活性分子。

项目成果

T.Kamada: "Diastereoselective α-Alkoxylation of Lactamide N-Alkyl Groups via Intramolecular Formation of Oxonium Ions as the Key Intermediate" J.Chem.Soc.Perkin 1. 3381-3388 (1998)

T.Kamada：“通过分子内形成氧鎓离子作为关键中间体对乳酰胺 N-烷基进行非对映选择性 α-烷氧基化”J.Chem.Soc.Perkin 1. 3381-3388 (1998)

A.Oku et al.: "Three-and Four-Carbon Elongating Ring-Expansion Reaction of Cyclic Acetals to Medium-Sized Dioxacycloalkenones.Utilization of Intramolecular Formation of Oxonium Ylides." J.Org.Chem.62. 2123-2129 (1997)

A.Oku 等人：“环状缩醛到中等尺寸二氧杂环烯酮的三碳和四碳扩环反应。氧鎓叶立德分子内形成的利用”。

鎌田 徹: "Diastereoselective a-Alkoxylation of Lactamide N-Alkyl Groups via Intramolecular Formation of Oxonium Ions as the Key Intermediate" J.Chem.Soc.Perkin 1. 3381-3388 (1998)

Toru Kamata：“通过分子内形成氧鎓离子作为关键中间体对乳酰胺 N-烷基进行非对映选择性 α-烷氧基化” J.Chem.Soc.Perkin 1. 3381-3388 (1998)

T.Harada et al.: "A Novel 1,2-Migration of Arylzincates Bearing a Leaving Group at Benzylic Position : Application to a Three-Component Coupling of p-Iodobenzyl Derivatives." Tetrahedron. 54. 9317-9332 (1998)

T.Harada 等人：“在苯甲基位置带有离去基团的芳基锌酸盐的新型 1,2-迁移：在对碘苄基衍生物三组分偶联中的应用”。

A.Oku: "Donor-Acceptor Photocatalysis System Illustrated by the Intramolecular Cyclization of a Cyclopropanone Acetal Tethered to Cyclohexen-2-one." Bull.Chem.Soc.Japan,. 72(in press). (1999)

A.Oku：“通过与环己烯-2-酮相连的环丙酮缩醛的分子内环化来说明供体-受体光催化系统。”