DEVELOPMENT OF HIGHLY EFFICIENT SEPARATION SYSTEM BY USING MOLECULAR AND ION RECOGNITION BY CALIXARENE COMPOUNDS

利用杯芳烃化合物分子和离子识别开发高效分离系统

基本信息

  • 批准号:
    09450293
  • 负责人:
  • 金额:
    $ 9.15万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    1997
  • 资助国家:
    日本
  • 起止时间:
    1997 至 1999
  • 项目状态:
    已结题

项目摘要

p-tert-octylcalix[4] arene and its monomeric analogue were synthesized to examine and compare their extraction behaviors for various metal ions, especially for lead ion. Lead was selectively extracted over iron(III) with the the former while reverse was the case with the latter reagent. From various experimental result of the extraction of different metal ions, it was elucidated that two lead ions are extracted by unit molecule of calix[4]arene carboxylate, which was confirmed by chemical shifts of H-NMR spectra before and after the extraction of lead ion.A molecular mechanics force field for lanthanoid complexes coordinated to organophosphates and calixarene compounds together with aqua ligands was presented. The ligand-metal-ligand (L-M-L) bending interaction are modeled with 1,3-nonbonded interaction and a harmonic M-L stretching potential was used for the stretching modes. There was good overall agreement between the observed and the calculated structural parameters. The calculatio … More ns also indicated that a quantitative structure property relationship (QSPR) may be obtained, which relates the complexation strain energy difference between the lanthanoid cations and La (III) with their relative extractability. Thus, molecular mechanics was found to be an efficient tool for the molecular design of organophosphorus and calixarene ligands with metal ion specific lanthanoid(III) extractability properties.A basic investigation on solvent extraction of catecholamines such as dopamine, adrenaline and noradrenaline from dilute hydrochloric acid was conducted using D2EHPA in chloriform, hexane and toluene. The stoichiometric relationship and equilibrium constants of the extraction reactions were evaluated. The quantitative structure property relationship of the equilibrium constant for each organic diluent was discussed using molecular modeling with semi-emperical molecular orbital calculations taking account of the diluent effect.New resin of calix[4]arenecarboxylate was synthesized from its monomeric units with no alkyl radicals by crosslinking using trioxane. High selectivity to lead and ferric ions were observed. The maximum adsorption capacity for lead was 2.44 mol/kg, which is nearly the same values of commercial chelating resins. Excellent mutual separation and concentration of lead away from zinc was achieved by using a column packed with this resin. Less
合成了对叔辛基杯芳烃及其单体类似物,考察并比较了它们对各种金属离子,特别是铅离子的萃取行为。前者选择性地从铁(III)上萃取铅,后者则相反。从提取不同金属离子的各种实验结果中,阐明了杯状[4]芳烃羧酸酯单位分子可提取两个铅离子,并通过提取铅离子前后H-NMR谱的化学位移证实了这一点。给出了类镧配合物与有机磷酸酯和杯芳烃配合物与水配体的分子力学力场。配体-金属-配体(L-M-L)弯曲相互作用模型采用1,3-非键相互作用,拉伸模式采用调和M-L拉伸势。观察到的结构参数与计算得到的结构参数总体上吻合良好。计算结果表明,类镧离子与La (III)的络合应变能差与其相对可萃取性之间存在定量结构性质关系(QSPR)。因此,分子力学被发现是具有金属离子特异性类镧(III)可萃取性的有机磷和杯芳烃配体的分子设计的有效工具。以D2EHPA、氯仿、己烷、甲苯为溶剂,对从稀盐酸中提取多巴胺、肾上腺素、去甲肾上腺素等儿茶酚胺进行了基础研究。考察了萃取反应的化学计量关系和平衡常数。利用分子模型和半经验分子轨道计算,讨论了考虑稀释剂效应的各有机稀释剂平衡常数的定量结构和性质关系。以不含烷基自由基的杯形羧酸酯单体为原料,采用三氧环交联法制备了新的杯形羧酸酯树脂。对铅、铁离子有较高的选择性。对铅的最大吸附量为2.44 mol/kg,与商业螯合树脂的吸附量基本一致。通过使用填充该树脂的色谱柱,实现了良好的相互分离和铅与锌的富集。少

项目成果

期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
K.Yoshizuka, Y.Fujimoto, K.Ohto, K.Inoue: "Solvent extraction and QSPR of cathecholamines with a bis(2-ethylhexyl)hydrogen phosphate"J. Chem. Eng. Japan. 22. 76-81 (1999)
K.Yoshizuka、Y.Fujimoto、K.Ohto、K.Inoue:“用双(2-乙基己基)磷酸氢盐对儿茶酚胺进行溶剂萃取和 QSPR”J。
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    0
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P.Comba et al.: "Malecular mechanics zalculations and the metal ion selective extraction of lanthanotds" Inorganic Chemistry. 37巻13号. 3310-3315 (1998)
P. Comba 等人:“马来力学计算和镧系元素的金属离子选择性萃取”,《无机化学》,第 37 卷,第 13 期。3310-3315 (1998)
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    0
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K.Yoshizuka, K.Inoue, K.Ohto et.al.: "Proceedings of International Soluvent extraction Conference 1999"QSPR of extractability trends of lanthanoid sertes using novel molecular mechanics calculations. 6 (2000)
K.Yoshizuka、K.Inoue、K.Ohto 等人:“1999 年国际溶剂萃取会议论文集”使用新颖的分子力学计算对镧系元素丝氨酸的萃取率趋势进行 QSPR。
  • DOI:
  • 发表时间:
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  • 影响因子:
    0
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K.Ohto, Y.Fujimoto, K.Inoue: "Stepwise extraction of two lead ions with a single molecule of calix[4]arene tetracarboxylate"Anal. Chim. Acta. 387. 61-69 (1999)
K.Ohto、Y.Fujimoto、K.Inoue:“用单分子杯[4]芳烃四羧酸盐逐步提取两个铅离子”Anal。
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  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
K.Yoshizuka et al.: "Soluent extraction and QSPR of catecholamines with bio(2-ethylhexyl)hydrogen phoophate" J.Chemical Engineering of Japan. 32巻1号. 76-81 (1999)
K. Yoshizuka 等人:“用生物(2-乙基己基)磷酸氢盐进行儿茶酚胺的溶剂萃取和 QSPR”,日本化学工程杂志,第 32 卷,第 1. 76-81 期(1999 年)。
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    0
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INOUE Katsutoshi其他文献

INOUE Katsutoshi的其他文献

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{{ truncateString('INOUE Katsutoshi', 18)}}的其他基金

Development of adsorbents for the removal of cesium using biomass wastes
开发利用生物质废物去除铯的吸附剂
  • 批准号:
    24656551
  • 财政年份:
    2012
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development of novel environmentally benign functional matarials for separation process using lignin derivatives
使用木质素衍生物开发用于分离过程的新型环保功能材料
  • 批准号:
    19560757
  • 财政年份:
    2007
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Control of the Functionality by selective modification on protein surface with calixarene compounds
通过杯芳烃化合物选择性修饰蛋白质表面来控制功能
  • 批准号:
    14350419
  • 财政年份:
    2002
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
INVESTIGATION ON DEVELOPMENT AND MOLECULAR DESIGN OF HIGH-PERFORMANCE SOLVENT EXTRACTION REAGENTS FOR RARE EARTHS
高性能稀土溶剂萃取试剂的开发及分子设计研究
  • 批准号:
    06650886
  • 财政年份:
    1994
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Fundamental investigation for the development of novel types of adsorption gels for immobilized metal affinity Chromatography
新型固定化金属亲和色谱吸附凝胶开发的基础研究
  • 批准号:
    03650605
  • 财政年份:
    1991
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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RUI:开发离子淌度质谱技术以确定金属离子识别的结构和机制
  • 批准号:
    1764436
  • 财政年份:
    2018
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    $ 9.15万
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    Standard Grant
Creation of nanofiber with ion recognition and reduction functions and development of innovative separation method
具有离子识别和还原功能的纳米纤维的创建以及创新分离方法的开发
  • 批准号:
    17K20067
  • 财政年份:
    2017
  • 资助金额:
    $ 9.15万
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    Grant-in-Aid for Challenging Research (Exploratory)
Development of grafted fibrous adsorbent having high metal ion recognition ability under super strong alkaline condition
超强碱性条件下具有高金属离子识别能力的接枝纤维吸附剂的研制
  • 批准号:
    17K14138
  • 财政年份:
    2017
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Synthesis and Cyanide Ion Recognition of Water Soluble Receptors
水溶性受体的合成及氰化物离子识别
  • 批准号:
    22550116
  • 财政年份:
    2010
  • 资助金额:
    $ 9.15万
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    Grant-in-Aid for Scientific Research (C)
Specific Metal Ion Recognition Mechanism by Protein Molecule
蛋白质分子识别特定金属离子的机制
  • 批准号:
    13640553
  • 财政年份:
    2001
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Syntheses of host molecules and evaluation for lithium ion recognition
主体分子的合成及锂离子识别评价
  • 批准号:
    09640697
  • 财政年份:
    1997
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Separation of lanthanide elements by ion recognition of polymer gel copolymerized with acidic phosphorus compound
酸性磷化合物共聚聚合物凝胶离子识别分离镧系元素
  • 批准号:
    09650840
  • 财政年份:
    1997
  • 资助金额:
    $ 9.15万
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    Grant-in-Aid for Scientific Research (C)
Synthesis and Application of Ion Recognition Compounds with High Sensitivities for Medical Science
高灵敏度医学离子识别化合物的合成及应用
  • 批准号:
    04557112
  • 财政年份:
    1992
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research (B)
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