Assessment of Vascularity andviability of the liver and liver tumors using the liver specific contrast agent in MR imaging

在 MR 成像中使用肝脏特异性造影剂评估肝脏和肝脏肿瘤的血管和活力

• 批准号: 09670921
• 负责人: ISHII Yasushi
• 金额: $ 2.24万
• 依托单位: Fukui Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670921/
• 关键词: magnetic resonance spectroscopy (MRS); positron emission tomography (PET); occlusive carotid artery disease; crebral ischemia; oxygen metabolism; 核磁気共鳴画像; 脳腫瘍; 代謝; positron cmission tomography(PET)

Carotid occlusive disease may cause ischemic change both in the gray and white matter as a result of hemodynamic compromize. To validate proton magnetic spectroscopy (MRS) in evaluating the carotid occlusive diseases, changes in peakes of choline (Cho), the sum of creatine and phosphocreatine (Cr) and N-acetylaspartate (NAA) of the white matter were compared with the cortical oxygen metabolism measured by positron emission tomography (PET). Eleven patients with unilateral steno-occlusive carotid artery disease underwent both PET and MRS.MRS was performed in the bilateral centrum smiovale, Regional cerebral blood flow, metabolic rate of oxygen (rCMRO2) and oxygen extraction fraction (rOEF) of the crebral cortex were measured by the PET.The asymmetry index(AI) of the NAA/Cr ratio correlated positively with that of rCMRO2(r=0.809, p<0.01). as rCMRO2 is a marker of tissue viability. NAA ratio may reflect viable neuronal component. The Al of the Cho/Cr raio showed significant correlation with that of rOEF (r=0.844. P<0.01). The peak of choline contained the precursors and degradative products in the membrane metabolism, This may indicate membrane damage due to ischemia, as the centrum smiovale is the deep watershed zone. ln conclusion, the metabolic change in centrum semiovale detected by proton MRS reflects a hemodynamically compromized state and usful in evaluating the viability of brain tissue.

颈动脉闭塞症可导致血流动力学损害，引起灰质和白质的缺血性改变。为验证质子磁共振波谱(MRS)在评价颈动脉闭塞性疾病中的价值，将脑白质胆碱峰值(CHO)、肌酸和磷酸肌酸(Cr)和N-乙酰天冬氨酸(NAA)的变化与正电子发射断层扫描(PET)测量的皮质氧代谢进行比较。对11例单侧颈动脉狭窄闭塞症患者进行了正电子发射计算机断层扫描和磁共振成像，并对双侧大脑中动脉进行了MRS检查，测量了大脑皮质局部脑血流量、氧代谢速率(RCMRO2)和氧摄取分数(ROEF)。因为rCMRO2是组织活力的标志。NAA比率可反映神经元的活性成分。Cho/CrRAIO的Al与Roef的Al呈显著正相关(r=0.844)。P&lt；0.01)。胆碱的峰含有膜代谢的前体和降解产物，这可能是由于缺血造成的膜损伤，因为斯氏中心是深层次的分水岭。结论：质子磁共振波谱检测到的半卵圆中心代谢改变反映了脑组织的血流动力学受损状态，有助于评价脑组织的生存能力。

项目成果

C.Tsuchida: "Proton MRS spectroscopy evaluation of brain metabolism in patients with stenoocclusive carotid artery disease : Correlation with cerebral blood flow and oxygen metabolsim by PET" Proceedings of 6th ISMRM. 3. 1733 (1988)

C.Tsuchida：“狭窄闭塞性颈动脉疾病患者脑代谢的质子 MRS 波谱评估：PET 与脑血流量和氧代谢的相关性”第六届 ISMRM 论文集。

Chika Tsuchida: "Proton MR spectroscopy evaluation of brain metabolism in patients with stenoocclusive carotid artery disease : Correlation with cerebral blood flow and oxygen metabolism by PET." Proceedings of 6th ISMRM. Vol.3. 1733 (1998)

Chika Tsuchida：“质子磁共振波谱评估狭窄闭塞性颈动脉疾病患者的脑代谢：PET 与脑血流量和氧代谢的相关性。”

Tsuchida, C.: "Proton MRS and PET oxygen metabolism in brains of occlusive carotid artery disease." The Journal of Nuclear Medicine. Vol. 39(Suppl.). 213P (1998)

Tsuchida, C.：“闭塞性颈动脉疾病大脑中的质子 MRS 和 PET 氧代谢。”

Tsuchida, C.: "Proton MRS and PET oxygen metabolism in brains of occlusive carotid artery disease." The Journal of Nuclear Medicine. Vol.39(Suppl.). 213P (1998)

Tsuchida, C.：“闭塞性颈动脉疾病大脑中的质子 MRS 和 PET 氧代谢。”

C.Tsuchida: "Proton MRS and PET oxygen metabolism in brains of occlusive carotid artery disease" The Journal of Nuclear Medicine. 39 (Suppl.). 213 (1998)

C.Tsuchida：“闭塞性颈动脉疾病大脑中的质子 MRS 和 PET 氧代谢”核医学杂志。