High resolution positron emission tomography (PET) insert systems for multimodality PET/magnetic resonance imaging
High resolution positron emission tomography (PET) insert systems for multimodality PET/magnetic resonance imaging
批准号:
RGPIN-2017-04963
负责人:
Goertzen, Andrew
金额:
$2.04万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2020
资助国家:
加拿大
项目状态:
已结题
起止时间:
2020-01-01 至 2021-12-31
中文摘要
正电子发射
断层扫描 (PET) 是一种成像方式,可以对组织进行非侵入性评估
在临床和临床前环境中在分子水平上发挥作用
通过对放射性标记示踪剂的生物分布进行成像。高
许多 PET 成像示踪剂的特异性导致图像中的解剖学特征很少
信息,使得很难将示踪剂吸收分配给特定的
组织并使图像的解释和分析变得复杂。的
这个问题的解决方案是将 PET 与解剖成像相结合
模态,最初是 X 射线计算机断层扫描 (CT),最近是磁力扫描
共振(MR)成像。 PET 与 MR 的整合用于临床前混合
小动物的 PET/MR 成像可以通过使用
PET 插入物适合现有高场 MR 系统的孔内,并且
可以与MR同时操作。在上一个融资周期中,我们
小组成功开发并部署了这种用于小动物的插入物
使用新型 MR 兼容硅光电探测器和多层的 PET/MR 成像
闪烁体阵列可在紧凑的环直径中保持空间分辨率
PET系统。用于临床前成像的 PET 插入系统现已成为
商业上可用的,包括基于我们的设计的商业化产品
一家加拿大公司。
在此应用程序中,我将基于我们的
用于小动物 PET/MR 的 PET 插入系统的专业知识,以实现我的长期目标
创建硬件和软件技术的术语目标
允许使用带有 PET 插入物的混合 PET/MR 成像作为常规成像
临床前小动物研究和人类神经影像学的模式
应用程序。为了实现这个目标,我的研究的短期目标
该提案中详细介绍的程序涵盖三个主题:i) 算法和硬件
推进临床前 PET/MR 成像; ii) 下一步探测器开发
新一代 PET 嵌件系统; iii) 创造技术以促进和
自动化小动物 PET/MR 成像。
这些研究目标创造了多学科
电气专业研究生和本科生的培训机会
工程学、生物医学工程和医学物理。密切合作
与临床前动物成像的成像系统的最终用户和
临床成像水平,与制造的工业合作伙伴一起
成像系统,促进新技术的快速测试和部署、集成
用户反馈的修订和新设备技术转化的路径。
英文摘要
Positron emission
tomography (PET) is an imaging modality that allows non-invasive assessment of tissue
function at the molecular level in both clinical and preclinical settings
through imaging the biodistribution of radioactively labelled tracers. The high
specificity of many PET imaging tracers results in images with little anatomical
information, making it difficult to assign the tracer uptake to specific
tissues and complicating the interpretation and analysis of the images. The
solution to this problem has been to integrate PET with an anatomical imaging
modality, initially X-ray computed tomography (CT) and more recently, magnetic
resonance (MR) imaging. Integration of PET with MR for preclinical hybrid
PET/MR imaging of small animals can be efficiently accomplished through using a
PET insert that fits within the bore of an existing high field MR system and
can operate simultaneously with the MR. During the previous funding cycle, our
group successfully developed and deployed such an insert for small animal
PET/MR imaging using new MR compatible silicon photodetectors and a multi-layer
scintillator array to preserve spatial resolution in the compact ring diameter
PET system. PET insert systems for preclinical imaging are now becoming
commercially available, including one based on our design commercialized through
a Canadian company.
In this application I will build on our
expertise in PET insert systems for small animal PET/MR to achieve my long
term objective of creating hardware and software technologies that
enable the use of hybrid PET/MR imaging with PET inserts as a routine imaging
modality in preclinical small animal research studies and in human neuroimaging
application. To achieve this goal, the short term objectives of my research
program detailed in this proposal cover three themes: i) algorithms and hardware
to advance preclinical PET/MR imaging; ii) detector development for next
generation PET insert systems; and iii) creating technologies to facilitate and
automate small animal PET/MR imaging.
These research objectives create multi-disciplinary
training opportunities for graduate and undergraduate students from Electrical
Engineering, Biomedical Engineering and Medical Physics. Close collaboration
with both end users of imaging systems at the preclinical animal imaging and
clinical imaging levels, together with industrial partners that manufacture
imaging systems, facilitates rapid testing and deployment of new technologies, integration
of user feedback for revisions and a path for technology translation of new devices.
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High resolution positron emission tomography (PET) insert systems for multimodality PET/magnetic resonance imaging
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批准号:RGPIN-2017-04963
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$4.08万
-
财政年份:2021
-
负责人:Goertzen, Andrew
-
依托单位:
Development of a PET insert for hybrid PET/MR neuroimaging
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批准号:536762-2019
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项目类别:Idea to Innovation
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资助金额:$7.74万
-
财政年份:2019
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负责人:Goertzen, Andrew
-
依托单位:
High resolution positron emission tomography (PET) insert systems for multimodality PET/magnetic resonance imaging
-
批准号:RGPIN-2017-04963
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.04万
-
财政年份:2019
-
负责人:Goertzen, Andrew
-
依托单位:
High resolution positron emission tomography (PET) insert systems for multimodality PET/magnetic resonance imaging
-
批准号:RGPIN-2017-04963
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.04万
-
财政年份:2018
-
负责人:Goertzen, Andrew
-
依托单位:
High resolution positron emission tomography (PET) insert systems for multimodality PET/magnetic resonance imaging
-
批准号:RGPIN-2017-04963
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.04万
-
财政年份:2017
-
负责人:Goertzen, Andrew
-
依托单位:
Technologies to advance hybrid multimodality positron emission tomography and magnetic resonance imaging
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批准号:341628-2012
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项目类别:Discovery Grants Program - Individual
-
资助金额:$1.31万
-
财政年份:2016
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负责人:Goertzen, Andrew
-
依托单位:
Technologies to advance hybrid multimodality positron emission tomography and magnetic resonance imaging
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批准号:341628-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.31万
-
财政年份:2015
-
负责人:Goertzen, Andrew
-
依托单位:
Applications of high speed digitizer systems in nuclear medicine imaging applications
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批准号:488371-2015
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项目类别:Engage Grants Program
-
资助金额:$1.82万
-
财政年份:2015
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负责人:Goertzen, Andrew
-
依托单位:
Extended field of view detectors for a MRI compatible positron emission tomography imaging system
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批准号:469136-2014
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项目类别:Idea to Innovation
-
资助金额:$9.11万
-
财政年份:2014
-
负责人:Goertzen, Andrew
-
依托单位:
Technologies to advance hybrid multimodality positron emission tomography and magnetic resonance imaging
-
批准号:341628-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.31万
-
财政年份:2014
-
负责人:Goertzen, Andrew
-
依托单位:
Imaging of antibody therapeutics in mouse models of Alzheimer's Disease
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批准号:462641-2014
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项目类别:Engage Grants Program
-
资助金额:$1.82万
-
财政年份:2014
-
负责人:Goertzen, Andrew
-
依托单位:
Interactions Grant to Explore High Speed Digitizers for Applications in Positron Emission Tomography
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批准号:477803-2014
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项目类别:Interaction Grants Program
-
资助金额:$0.22万
-
财政年份:2014
-
负责人:Goertzen, Andrew
-
依托单位:
Technologies to advance hybrid multimodality positron emission tomography and magnetic resonance imaging
-
批准号:341628-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.31万
-
财政年份:2013
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负责人:Goertzen, Andrew
-
依托单位:
Monte Carlo based optimization of detector designs for positron emission tomography
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批准号:453223-2013
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项目类别:Engage Grants Program
-
资助金额:$1.82万
-
财政年份:2013
-
负责人:Goertzen, Andrew
-
依托单位:
Technologies to advance hybrid multimodality positron emission tomography and magnetic resonance imaging
-
批准号:341628-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.31万
-
财政年份:2012
-
负责人:Goertzen, Andrew
-
依托单位:
Improving quantification of weak sources in positron emission tomography
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批准号:341628-2007
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项目类别:Discovery Grants Program - Individual
-
资助金额:$1.78万
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财政年份:2011
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负责人:Goertzen, Andrew
-
依托单位:
Improving quantification of weak sources in positron emission tomography
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批准号:341628-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.78万
-
财政年份:2010
-
负责人:Goertzen, Andrew
-
依托单位:
Improving quantification of weak sources in positron emission tomography
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批准号:341628-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.78万
-
财政年份:2009
-
负责人:Goertzen, Andrew
-
依托单位:
Improving quantification of weak sources in positron emission tomography
-
批准号:341628-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.78万
-
财政年份:2008
-
负责人:Goertzen, Andrew
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依托单位:
High sensitivity detectors for positron emission tomography
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批准号:360020-2008
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项目类别:Research Tools and Instruments - Category 1 (<$150,000)
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资助金额:$5.77万
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财政年份:2007
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负责人:Goertzen, Andrew
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依托单位:
国内基金
海外基金
基于飞行时间技术的新一代正电子发射断层扫描技术研究
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批准号:10775149
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项目类别:面上项目
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资助金额:40.0万元
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批准年份:2007
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负责人:魏龙
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依托单位: