Development of rasonable parathyroidectomy employing intraoperative gamma probe

术中伽马探针合理甲状旁腺切除术的进展

• 批准号: 09671252
• 负责人: TAKAMI Hiroshi
• 金额: $ 2.3万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671252/
• 关键词: Hyperparathyroidism; Parathyroidectomy; Intraoperative localization test; 99mTc-sestamibi; gamma probe; 副甲状腺摘出術; ^<99m>Tc-sestamibi

1. MethodSix patients with primary hyperparathyroidism who were not operated before (primary case) were underwent ipsilateal parahyroidectomy. The patients were scanned early morning of the operation with 99msestaMIBl.Two patients with persitstent hyperparathyroidism who were operated in anther hospital were underwent re-parathyroidectomy.2 .ResultsThe location where adenomas were located showed higher levels of MIBI (6.8 gamma counts per sec(thousand). The other location(control) revealed 4.6 gamma counts per sec(thousand). The adenomas were resected 21 mimutes after skin incision. 8.2 gamma counts on the time of resection decreased to 3 gamma counts after removal of adenomas. Postoperative calcium and PTH levels showed within normal levels.The adenomas of the two persitent hypercalcemic patients were the following : the first case were located between right common carotid artery and vagus nerve, and posteror aspect of the superior pole of the thyroid. The second patients is locacted at the behind of the esophagus. Postoperative calcium and Ff11 levels showed within normal levels.

1. 方法对6例未经手术治疗的原发性甲状旁腺功能亢进患者（原发病例）行同侧甲状旁腺切除术。患者于手术当天清晨进行99msestaMIBl扫描。2例顽固性甲状旁腺功能亢进患者于其他医院行甲状旁腺切除术。2 ．结果腺瘤所在部位的MIBI水平较高（6.8次/秒（千））。另一个位置（对照组）显示每秒4.6次伽马计数（千次）。皮肤切开后21分钟切除腺瘤。切除时的8.2个伽马计数在腺瘤切除后下降到3个伽马计数。术后钙、甲状旁腺素均在正常范围内。2例持续性高钙血症患者的腺瘤如下：1例位于右颈总动脉与迷走神经之间，甲状腺上极后侧。第二例患者位于食道后部。术后钙和Ff11水平均在正常范围内。

项目成果

Kubo, A.: "Snwessful Tc-99mMIBI imaging of recuvent hyperparathy voidisk in mathyroid autotransp lanted patients" Clin Nncl Med. 22. 872-874 (1997)

Kubo, A.：“甲状腺自体移植患者复发性甲状旁腺功能亢进性空虚症的 Snwessful Tc-99mMIBI 成像”Clin Nncl Med。

高見 博: "副甲状腺機能亢進症の内視鏡手術" ホルモンと臨床. 46. 741-745 (1998)

Hiroshi Takami：“甲状旁腺功能亢进症的内窥镜手术”激素与临床科学 46. 741-745 (1998)。

Takami, H.: "Surgical management of hyperpara thyroidism in view of a reliable parethyroid adenoma localization test" Surgery. 122. 120 (1997)

Takami, H.：“鉴于可靠的甲状旁腺腺瘤定位测试，对甲状旁腺功能亢进症进行手术治疗”。

日下部 きよ子: "過機能性副甲状腺結節の検出における99mtc-MIBIシンチグラフィーの臨床的有用本" 核医学. 35. 887-899 (1998)

Kiyoko Kusakabe：“99mtc-MIBI 闪烁扫描技术在检测功能亢进的甲状旁腺结节中的临床有用书籍”核医学 35. 887-899 (1998)。

Kubo, A.: "Successful Tc-99mMIBI imaging of recurrent hyperparathyroidism in parathyroid autotransplanted patients." Cli Nucl Med. 22. 872-874 (1997)

Kubo, A.：“成功对甲状旁腺自体移植患者复发性甲状旁腺功能亢进症进行 Tc-99mMIBI 成像。”