A study on new diagnosis and treatment by receptorscintigraphy for neuroendocrine tumor

神经内分泌肿瘤受体显像新诊治研究

• 批准号: 05671027
• 负责人: TAKAMI Hiroshi
• 金额: $ 1.34万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671027/
• 关键词: neuroendocrine tumor; carcinoid; somatostatin receptor; receptor scintigraph

1.Receptorscintigraphy in nudemouse1) Scentigraphy was performed employing 125I- (Tyr11) SRIF.Content of Somatostatin in human neuroendocrine tumors was positive in one case of carcinoid of transverse colon among 3 cases of medullary thyroid carcinoma and 2 cases of carcinoids. Radioligand showed (125I) LTT-SRIF-28 adn IC50 was o.31 nmol/L.2) The nude mouse used was BALB/c (6 w/o), male and 16-20g at wight. The experiments were started form 23 days after inoculation. The insulinoma which showed positive somatostatin receptor and were gifted revealed positive accumulation of 125I- (Tyr) SRIF at tumor itself. At the first day after inoculation, sotope was trapped into liver and thyroid, but at third day specificity of scintigraphy was increased. Therefore, this scintigraphic system was thought to be meaningful.

1.裸鼠受体扫描采用125I- (Tyr11) SRIF扫描。3例甲状腺髓样癌和2例类癌中，横结肠类癌1例生长抑素含量阳性。放射配体显示（125I） LTT-SRIF-28， IC50为0.31 nmol/L。2)所用裸鼠为BALB/c (6 w/o)，雄性，体重16-20g。接种后23 d开始试验。在生长抑素受体阳性的胰岛素瘤中发现125I- (Tyr) SRIF在肿瘤本身呈阳性积累。在接种后第1天，sotope被捕获到肝脏和甲状腺中，但在第3天，闪烁成像的特异性增加。因此，这个科学系统被认为是有意义的。

项目成果

高見 博: "消化管ホルモン産生腫瘍に対する内分泌療法" KARKINOS. 7. 63-66 (1994)

Hiroshi Takami：“胃肠道激素产生肿瘤的内分泌治疗”KARKINOS 7. 63-66 (1994)。

高見博: "消化管ホルモン産生腫瘍に対する内分泌療法" KARKINOS. 7. 63-66 (1994)

Hiroshi Takami：“胃肠道激素产生肿瘤的内分泌治疗”KARKINOS 7. 63-66 (1994)。

Hiroshi Takami: "Endocrine therapy for hormone producing tumor of the alimentary tract" KARKINOS. 7. 63-66 (1994)

Hiroshi Takami：“消化道产生激素的肿瘤的内分泌治疗”KARKINOS。