Myocardial tactile stiffness

心肌触觉僵硬

基本信息

  • 批准号:
    09671364
  • 负责人:
  • 金额:
    $ 1.98万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1997
  • 资助国家:
    日本
  • 起止时间:
    1997 至 1999
  • 项目状态:
    已结题

项目摘要

Background. Evaluation of regional myocardial contractile function is of clinical importance. We have developed a new tactile sensor system for accurate measurement of myocardial stiffness in situ. We found that thc myocardial stiffness measured by this sensor, which we call tactile stiffness, can be a very useful index for accurate quantification of regional myocardial function. In this study, we used a coronary stenosis model to investigate regional myocardial tactile stiffness under conditions of reduced coronary blood flow.Methods. The myocardial tactile stiffness, coronary blood flow, and ventricular pressure and volume, of five open chest mongrel dogs weighing 15 to 17 kg, were measured. After measuring the baseline myocardial stiffness, coronary arterial stenosis was induced with a balloon occluder.Results. Reducing the coronary flow to 50% and 25% of the baseline level reduced the end-systolic tactile stiffness significantly from 2.20 ± 0.16 g/mm2 to 2.05 ± 0.20 g/mm2 (p < 0.05) and from 2.21 ± 0.16 g/mm2 to 1.96 ± 0.18 g/mm2 (p < 0.01), respectively. Reducing the flow, to 50% and 25%, increased the end-diastolic stiffness significantly from 1.29 ± 0.15 g/mm2 to 1.39 ± 0.14 g/mm2 (p < 0.01) and from 1.30 ± 0.16 g/mm2 to 1.46 ± 0.14 g/mm2 (p < 0.05), respectively. Conclusions. We consider that the regional myocardial tactile stiffness will be a useful index sensitive enough to detect changes in regional contractile function under conditions of reduced, coronary blood flow.
背景评价局部心肌收缩功能具有重要的临床意义。我们开发了一种新的触觉传感器系统,用于精确测量原位心肌硬度。我们发现,由该传感器测量的心肌硬度,我们称之为触觉硬度,可以作为精确定量局部心肌功能的一个非常有用的指标。在这项研究中,我们使用了冠状动脉狭窄模型,以研究在冠状动脉血流减少的条件下局部心肌触觉刚度。对5只体重15 ~ 17 kg的开胸杂种犬的心肌触觉硬度、冠状动脉血流量、心室压力和容积进行了测量。在测量基线心肌硬度后,用球囊封堵器诱导冠状动脉狭窄。将冠状动脉流量减少到基线水平的50%和25%,收缩末期触觉硬度分别从2.20 ± 0.16 g/mm 2显著降低到2.05 ± 0.20 g/mm 2(p < 0.05)和从2.21 ± 0.16 g/mm 2显著降低到1.96 ± 0.18 g/mm 2(p < 0.01)。将血流减少至50%和25%,舒张末期刚度分别从1.29 ± 0.15 g/mm 2显著增加至1.39 ± 0.14 g/mm 2(p < 0.01)和从1.30 ± 0.16 g/mm 2显著增加至1.46 ± 0.14 g/mm 2(p < 0.05)。结论.我们认为,区域心肌触觉刚度将是一个有用的指标,足够敏感,以检测局部收缩功能的变化条件下减少,冠状动脉血流量。

项目成果

期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Miyaji, K.: "Myocardial tactile stiffness during acute reduction of coronary blood flam"Aunals of Thoracic Surgery. 69. 151-5 (2000)
Miyaji, K.:“冠状动脉血流急性减少过程中的心肌触觉僵硬”胸外科协会。
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    0
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  • 通讯作者:
Miyaji, K.: "Myocardial tactile stiffness: a variable of regional myocardial function"Journal of American College of Cardiology. 31. 1165-73 (1998)
Miyaji, K.:“心肌触觉僵硬:局部心肌功能的变量”美国心脏病学会杂志。
  • DOI:
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    0
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Miyaji, K.: "Regional myocardial stiffness measured by a new tactile sensor system"Japanese Heart Journal. 38. 709-15 (1997)
Miyaji, K.:“通过新的触觉传感器系统测量的区域心肌僵硬度”日本心脏杂志。
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    0
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Miyaji, K.: "The stiffness of lymphonodes containing lung carcinoma metastases"Cancer. 80. 1920-5 (1997)
Miyaji, K.:“含有肺癌转移的淋巴结僵硬”癌症。
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  • 发表时间:
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  • 影响因子:
    0
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Nakajima J, Furuse A, Kohno T, Ohtsuka T, Matsumoto J, Oka T.: "Transthoracoscopic needle biopsy for indeterminate lung nodules."Surg Endosc.. 13. 386-389 (1999)
Nakajima J、Furuse A、Kohno T、Ohtsuka T、Matsumoto J、Oka T.:“经胸腔镜针活检用于不确定的肺结节。”Surg Endosc.. 13. 386-389 (1999)
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TANAKA Makoto其他文献

TANAKA Makoto的其他文献

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{{ truncateString('TANAKA Makoto', 18)}}的其他基金

Examination of the infuluence of zinc on the expression of taste receptor genes(T1Rs) in the rat tongue
锌对大鼠舌味觉受体基因(T1Rs)表达影响的研究
  • 批准号:
    26861422
  • 财政年份:
    2014
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Strategic banking under imperfect competition: Dynamic analysis of emissions permit and power banking
不完全竞争下的战略银行:排放许可与电力银行的动态分析
  • 批准号:
    26380291
  • 财政年份:
    2014
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Establishment of treatment method by whole body administration of gene modification BM-MSC in acute lung injury
基因修饰BM-MSC全身给药治疗急性肺损伤方法的建立
  • 批准号:
    25670610
  • 财政年份:
    2013
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development of a patient orientated self-management approach for people with inflammatory bowel disease: a preliminary study
为炎症性肠病患者制定以患者为导向的自我管理方法:初步研究
  • 批准号:
    22792175
  • 财政年份:
    2010
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
An analysis on emissions trading with forward and spot markets under oligopolistic competition
寡头竞争下远期和现货市场排放权交易分析
  • 批准号:
    22530220
  • 财政年份:
    2010
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Provision of required information for patients with inflammatory bowel disease
为炎症性肠病患者提供所需信息
  • 批准号:
    19791683
  • 财政年份:
    2007
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Effects of reflex circulatory regulation on cardiac morbidity and mortality: influences of gender and menstrual cycle
反射性循环调节对心脏发病率和死亡率的影响:性别和月经周期的影响
  • 批准号:
    17591610
  • 财政年份:
    2005
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Molecular mechanisms that specify the cardiac cell lineage
指定心肌细胞谱系的分子机制
  • 批准号:
    15590738
  • 财政年份:
    2003
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effects of acidosis on cardiotonic effect of forskolin
酸中毒对毛喉素强心作用的影响
  • 批准号:
    14571418
  • 财政年份:
    2002
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Establishment of ES cell-derived cardiac myocyte culture system and clarification of the mechanism for determination of the cardiac cell lineage
ES细胞来源的心肌细胞培养体系的建立及心肌细胞谱系测定机制的阐明
  • 批准号:
    13832003
  • 财政年份:
    2001
  • 资助金额:
    $ 1.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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使用自由呼吸磁共振弹性成像方法评估衰老、性别差异以及女性更年期过渡过程中心肌僵硬度的自然演变
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