The role of diffuse myocardial fibrosis in myocardial stiffness

胶原蛋白是疤痕的主要成分，在一些心脏中积聚，我们可能会认为这会增加僵硬，威胁心脏功能。我们已经在心脏磁共振成像(MRI)上显示心脏松弛不良与胶原蛋白增加相关。我们的目标是在MRI表现和心脏僵硬的直接测量之间建立联系，在僵硬程度和胶原含量之间建立联系，以及抗纤维化治疗对心脏胶原的影响；帮助诊断、预后和结果。

Collagen, a major component of scar, accumulates in some hearts and we may expect this to increase stiffness, threatening heart function. We have shown poor heart relaxation correlates with increased collagen on heart magnetic resonance imaging (MRI). We aim to establish a link between MRI findings and direct measures of heart stiffness, a link between degree of stiffness and amount of collagen and effects of anti-fibrotic therapy on heart collagen; aiding diagnosis, prognosis and outcome.