The role of diffuse myocardial fibrosis in myocardial stiffness

弥漫性心肌纤维化在心肌僵硬度中的作用

• 批准号: nhmrc : 1072751
• 负责人: Dr Leah Iles
• 金额: $ 25.21万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-diffuse-myocardial-myocardial-stiffness/455527
• 关键词: role; diffuse; myocardial; fibrosis; stiffness

Collagen, a major component of scar, accumulates in some hearts and we may expect this to increase stiffness, threatening heart function. We have shown poor heart relaxation correlates with increased collagen on heart magnetic resonance imaging (MRI). We aim to establish a link between MRI findings and direct measures of heart stiffness, a link between degree of stiffness and amount of collagen and effects of anti-fibrotic therapy on heart collagen; aiding diagnosis, prognosis and outcome.

胶原蛋白是疤痕的主要成分，在一些心脏中积聚，我们可能会认为这会增加僵硬，威胁心脏功能。我们已经在心脏磁共振成像(MRI)上显示心脏松弛不良与胶原蛋白增加相关。我们的目标是在MRI表现和心脏僵硬的直接测量之间建立联系，在僵硬程度和胶原含量之间建立联系，以及抗纤维化治疗对心脏胶原的影响；帮助诊断、预后和结果。