THE ROLE OF THE OTOLITHIC ORGANS AND SENSORY CELLS IN THE SEMICIRCULAR CANALS TO CALORIC NYSTAGMUS

半规管中的耳石器官和感觉细胞对热性眼球震颤的作用

• 批准号: 09671764
• 负责人: ARAI Yasuko
• 金额: $ 1.02万
• 依托单位: TOKYO WOMEN'S MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671764/
• 关键词: caloric nystagmus; otolith organ; semicircular-canal-plugging; convection of endolymph; velocity storage; 3D eye recording; monkey; 有毛細胞; 3次元; ハト

The main source of caloric nystagmus was thought to be convection flow of endolymph in the lateral semicircular canal. However, the active caloric nystagmus in the micro-gravity disclosed the importance of non-convective componentThis research dealt with three-dimension analysis of caloric nystagmus before and after all-semicircular-canal plugging in monkeys as a joint research with Professor B.Cohen's group of Mount Sinai Medical Center New York University. We found that 1)all-canal-plugging did not abolish caloric nystagmus, and that 2)the head vertical component of caloric nystagmus in tilted position was spatially fixed before plugging that was changed to be head fixed after plugging and that 3)the spatially vertical component was related to the body vertical component. The success of plugging surgery was confirmed physiologically and also anatomically for the animal fulfilled all scheduled experiments. These results showed that the change of temperature in the inner ear can induce nystagmus without convection flow, yet influenced by gravitational force.The effect of localized hair-cell lesions of the lateral canal was planned using a small experimental animals (pigeon). To establish the methodology for three-dimension analysis of the freely moving head was not accomplished during this period of time.

热性眼球震颤的主要来源被认为是外半规管内淋巴的对流。本研究与美国纽约大学西奈山医学中心B.Cohen教授小组合作，对猕猴半规管封堵前后的热性眼震进行了三维分析。结果发现：（1）全根管堵塞并不能消除热性眼震;（2）倾斜位热性眼震的头部垂直分量在堵塞前为空间固定，堵塞后变为头部固定;（3）空间垂直分量与体部垂直分量相关。从生理学和解剖学上证实了封堵手术的成功，动物完成了所有计划的实验。这些结果表明，内耳温度的变化可以引起眼球震颤，而不对流，但重力的影响。在这段时间内，尚未建立自由移动头部的三维分析方法。