Three dimensional analysis of caloric nystagmus -canal-otolith interaction-

热量眼球震颤的三维分析-耳管-耳石相互作用-

• 批准号: 11671707
• 负责人: ARAI Yasuko
• 金额: $ 1.54万
• 依托单位: TOKYO WOMEN'S MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671707/
• 关键词: caloric nystagmus; three dimension analysis; semicircular canal plugging; post-rotatory nystagmus; non-invasive measurement; cinomolgus monkeys; pigeon; reconstruction of membranous labyrinth; 神経切断実験; 頭振; 非侵襲的; サル

The head investigator Arai found that three dimension analysis of normal and selective canal plugged caloric nystagmus in monkeys suggested gravitational orienting other than convection, and that semicircular canal plugging did not abolish caloric nystagmus. In order to explain these phenomena, Arai performed present project.Arai analyzed three dimension caloric nystagmus in different head positions relative to gravity from normal and all 6-semicircular-canal plugged monkeys. This revealed (1) close correlation of the orientation of nystagmus between head vertical component and earth vertical component, (2) convection current in the canals was lost after plugging , (3) position dependency of the amount of response was also lost after plugging. Hystrological examination of one animal showed boney occlusion of the membranous canals with intact sensory cells. Arai explained caloric nystagmus as the summated response.of (1) thermal convection which is lost after plugging, (2) cooling of all of the canal nerves, (3) pressure effect by thermal volume change which is enhanced after plugging canals, and (4) otolith orientation via velocity storage. Model based approach for the all canal plugged caloric response fitted to the actual responses.Three dimensional reconstruction of the membranous labyrinth from the serial section of the monkeys' bilateral temporal bones was almost finished by Uoda.Nishida established non invaisive, non restricted measurements of the head rotation in pigeons, using two synchronous video movies.

首席研究员Arai发现，对正常和选择性导管堵塞的猴子卡路里眼球震颤的三维分析表明，重力方向而不是对流，并且半规管堵塞并不能消除卡路里眼球震颤。为了解释这些现象，Arai执行了本项目。Arai分析了正常和所有6半规管堵塞的猴子在不同头部位置相对于重力的三维热性眼球震颤。这表明(1)头部垂直分量与地面垂直分量之间的眼震方向密切相关，(2)封堵后通道内的对流电流消失，(3)封堵后响应量的位置依赖性也消失了。一只动物的尿道学检查显示膜管骨质闭塞，感觉细胞完好。Arai解释说，热性眼震是(1)堵塞后失去的热对流，(2)所有神经管的降温，(3)堵塞后增强的热容量变化的压力效应，以及(4)速度储存导致的耳石定向的综合反应。基于模型的方法对全管堵塞的冷热反应符合实际反应。从猴的双侧颞骨连续切片上重建膜迷路的三维重建几乎由UOD完成。西田利用两部同步视频电影建立了非侵入性、无限制的鸽子头部旋转测量。

项目成果

Yasuko Arai and Jun-ichi Suzuki: "Afternuystagmus from calorization appears at the peak of the first phase -a study in monkeys after plugging all semicircular canals."Equilibrium Research, clinical cquilibriometry and modern treatment. Pp 349-358, ed CF C

Yasuko Arai 和 Jun-ichi Suzuki：“热化后震颤出现在第一阶段的峰值——一项在猴子身上进行的堵塞所有半规管的研究。”平衡研究、临床平衡测量和现代治疗。

Yasuko Arai: "A new light on caloric -What was disclosed by three dimensional analysis of caloric nystarmus?"Biological Sciences in Space. 15 (4) (in press).

Yasuko Arai：“热量的新认识 - 热量夜视症的三维分析揭示了什么？”太空生物科学。

Yasuko Arai: "A new light on caloric test -What was disclosed by three dimensional analysis of caloric nystagmus?"Biological Sciences in Space. 15(in press). (2002)

Yasuko Arai：“热量测试的新亮点 - 热量眼球震颤的三维分析揭示了什么？”太空生物科学。

Yasuko Arai, Sergei Yakushin, Jun-ichi Suzuki, Bernard Cohen: "Duration of effective caloric thermal stimulation in caloric test"Equilibrium Res. 59. 206-214 (2000)

Yasuko Arai、Sergei Yakushin、Jun-ichi Suzuki、Bernard Cohen：“热量测试中有效热量热刺激的持续时间”平衡研究。

新井寧子 鈴木淳一: "温度眼振検査における有効刺激の持続時間について"Equilibrium Research. 59(2). (2000)

Yasuko Arai 和 Junichi Suzuki：“温度眼球震颤测试中的有效刺激持续时间”平衡研究 59(2)。