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Correlation between semicircular ocular reflex and otolith ocular reflex and its application for clinical diagnosis using off-vertical axis rotation(OVAR)

半圆眼反射与耳石眼反射的相关性及其在离垂直轴旋转（OVAR）临床诊断中的应用

基本信息

批准号：
09671768
负责人：
KOIZUKA Izumi
金额：
$ 2.18万
依托单位：
St.Marianna University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

The vestibulo-ocular reflex(VOR) produces compensatory eye movements during head movements. The VOR consists of the angular VOR and the linear VOR. The VOR is under adaptive control that corrects VOR performance when visual-vestibular mismatch arises during head movements. Most experiments concerning plasticity of the VOR have used the semicircular-ocular reflex(ScOR). So far, there has been no investigation on the effect of adaptive plasticity of the otolith-ocular reflex(OOR) on the ScOR. In this study, using a linear sled, we tested the hypothesis that the ScOR is altered by changes in the OOR. To modify the OOR, we used an adaptation paradigm. Eight subjects were rotated sinusoidally at 0.125 Hz and 60 deg/sec peak angular acceleration for 40 minutes, while viewing earth-fixed vertical stripes on the wall while wearing the binocular magnifying lenses (x 2 paradigm). Four subjects were rotated sinusoidally for 40 minutes, while viewing head-fixed LED (x 0 paradigm). In the x 2 paradigm, 6 of the 8 subjects showed an increase in OOR sensitivity after adaptation. Each of the 6 subjects who showed an increase in OOR sensitivity after adaptation also showed an increased ScOR gain at 0.125Hz. In the x 0 paradigm, 2 of the 4 subjects showed a decrease in OOR sensitivity after adaptation. Each of the 2 subjects who showed an decrease in OOR sensitivity after adaptation also showed an decrease ScOR gain at 0.125Hz. These results suggest that the OOR and the ScOR share common neural pathways in such a way that a change in the synaptic efficacy of one pathway is accompanied by a commensurate change in the other.

前庭眼反射（VOR）在头部运动期间产生代偿性眼球运动。 VOR 由角度 VOR 和线性 VOR 组成。 VOR 处于自适应控制之下，当头部运动期间出现视觉前庭不匹配时，可以纠正 VOR 性能。大多数有关VOR可塑性的实验都使用半圆眼反射（ScOR）。迄今为止，尚未研究耳石眼反射（OOR）的适应性可塑性对ScOR的影响。在本研究中，我们使用线性雪橇测试了 ScOR 因 OOR 变化而改变的假设。为了修改 OOR，我们使用了适应范例。八名受试者以 0.125 Hz 和 60 度/秒峰值角加速度正弦旋转 40 分钟，同时佩戴双目放大镜（x 2 范例）观看墙上固定的垂直条纹。四名受试者正弦旋转 40 分钟，同时观看头部固定 LED（x 0 范例）。在 x 2 范式中，8 名受试者中有 6 名在适应后表现出 OOR 敏感性的增加。在适应后表现出 OOR 敏感性增加的 6 名受试者中的每一位也表现出在 0.125Hz 处的 ScOR 增益增加。在 x 0 范式中，4 名受试者中有 2 名在适应后表现出 OOR 敏感性下降。适应后表现出 OOR 敏感性下降的 2 名受试者中的每一位也表现出 0.125Hz 处 ScOR 增益的下降。这些结果表明，OOR 和 ScOR 共享共同的神经通路，即一个通路突触功效的变化伴随着另一个通路的相应变化。