Correlation between semicircular ocular reflex and otolith ocular reflex and its application for clinical diagnosis using off-vertical axis rotation(OVAR)

前庭眼反射（VOR）在头部运动时产生代偿性眼球运动。VOR分为角型VOR和线性型VOR。当头部运动时视觉-前庭不匹配产生时，VOR在自适应控制下纠正VOR性能。大多数关于视静脉可塑性的实验都使用了半圆眼反射（ScOR）。耳石-眼反射（OOR）的适应性可塑性对ScOR的影响尚未见报道。在本研究中，我们使用线性滑橇测试了ScOR随OOR变化而改变的假设。为了修改OOR，我们使用了一种适应范式。8名受试者以0.125 Hz和60°/秒的峰值角加速度正弦旋转40分钟，同时戴上双眼放大镜（x2范式）观察墙上固定在地面上的垂直条纹。四名受试者旋转40分钟，同时观看头部固定的LED （x 0范式）。在x2范式中，8名受试者中有6名在适应后表现出OOR敏感性的增加。在适应后表现出OOR敏感性增加的6名受试者中，每名受试者在0.125Hz时也表现出增加的scoor增益。在x 0范式中，4名受试者中有2名在适应后表现出OOR敏感性下降。适应后表现出OOR敏感性下降的2名受试者在0.125Hz时也表现出scoor增益的下降。这些结果表明，OOR和ScOR以这样一种方式共享共同的神经通路，即一个通路的突触效能的变化伴随着另一个通路的相应变化。

The vestibulo-ocular reflex(VOR) produces compensatory eye movements during head movements. The VOR consists of the angular VOR and the linear VOR. The VOR is under adaptive control that corrects VOR performance when visual-vestibular mismatch arises during head movements. Most experiments concerning plasticity of the VOR have used the semicircular-ocular reflex(ScOR). So far, there has been no investigation on the effect of adaptive plasticity of the otolith-ocular reflex(OOR) on the ScOR. In this study, using a linear sled, we tested the hypothesis that the ScOR is altered by changes in the OOR. To modify the OOR, we used an adaptation paradigm. Eight subjects were rotated sinusoidally at 0.125 Hz and 60 deg/sec peak angular acceleration for 40 minutes, while viewing earth-fixed vertical stripes on the wall while wearing the binocular magnifying lenses (x 2 paradigm). Four subjects were rotated sinusoidally for 40 minutes, while viewing head-fixed LED (x 0 paradigm). In the x 2 paradigm, 6 of the 8 subjects showed an increase in OOR sensitivity after adaptation. Each of the 6 subjects who showed an increase in OOR sensitivity after adaptation also showed an increased ScOR gain at 0.125Hz. In the x 0 paradigm, 2 of the 4 subjects showed a decrease in OOR sensitivity after adaptation. Each of the 2 subjects who showed an decrease in OOR sensitivity after adaptation also showed an decrease ScOR gain at 0.125Hz. These results suggest that the OOR and the ScOR share common neural pathways in such a way that a change in the synaptic efficacy of one pathway is accompanied by a commensurate change in the other.