Research of Gene therapy for patients with head and neck carcinomas using CyclinD1
Research of Gene therapy for patients with head and neck carcinomas using CyclinD1
批准号:
09671772
负责人:
KUMAZAWA Hirobumi
金额:
$1.92万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1999
中文摘要
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英文摘要
The grading of biological malignancy was studied in patients with head and neck squamous cell carcinomas. The studies concerning the amplification of the cyclinD1 gene and overexpression of cyclinD1 protein in head and neck squamous cell carcinomas were studied to evaluate the prognostic significance of patients. The amplification of cyclinD1 gene and overexpression of cyclinD1 protein in head and neck squamous cell carcinomas were considered to be useful for assessment of biological malignancy and prognosis in head and neck squamous cell carcinomas. These results suggest the approach for genetherapy using cyclinD1 for patients with head and neck carcinomas.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
熊澤博文: "頭頚部癌治療の最前線-悪性度診断-" 癌の臨床. 44・11. 1183-1191 (1998)
Hirofumi Kumazawa:“头颈癌治疗的前沿 - 恶性肿瘤诊断”《癌症临床》44・11(1998)。
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通讯作者:
Ryoichi Kyomoto: "Cyclin D1-Gene amplification is amore important prognostic factor than its protein over-expression in human head and ueak carcium" Int.J.Cancer. 74・6. 576-581 (1997)
Ryoichi Kyomoto:“细胞周期蛋白 D1 基因扩增是比人类头部和 ueak 钙中蛋白质过度表达更重要的预后因素”Int.J.Cancer 74・6 (1997)。
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通讯作者:
R.Kyomoto, H.Kumazawa, Y.Toda, N.Sakaida, et al: "CYCLIN-D1-GENE ANPLIFICATION IS A MORE POTENT PROGNOSTIC FACTOR THAN ITS PROTEIN OVER-EXPRESSION IN HUMAN HEAD-AND-NECK SQUAMOUS-CELL CARCINOMA" Int.J.Cancer. 74. 576-581 (1997)
R.Kyomoto、H.Kumazawa、Y.Toda、N.Sakaida 等人:“在人类头颈鳞状细胞癌中,CYCLIN-D1-基因扩增是比蛋白质过度表达更有效的预后因素”
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通讯作者:
Study for treatment of head and neck cancer by the mechanism of a poptosis
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批准号:06671742
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1994
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负责人:KUMAZAWA Hirobumi
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依托单位:
海外基金