Study for treatment of head and neck cancer by the mechanism of a poptosis

点击翻译按钮获取中文摘要

Apoptosis is a specific mode of cell death characterized by morphological, biological and molecular changes. Cell death by apoptosis is common in normal tissues and with organ involution and in cytotoxic immunological reactions. This mode of cell death in neoplastic tissues has recently become a focus of interest. Since little is known of apoptosis inhead and neck tumors, we studied the morphological changes in head and neck tumor-derived cell lines (KB,KBrc, HSC-2,3,4) in the in vitro experimental assay. Furthermore, we tried to use the apoptotic reaction for overcoming CDDP resistance. In the in vivo model, which we developed using nude mouse model, we observed CDDP resistance after multiple application of 254-S.However, the apoptotic reaction did not overcome the resistance of 254-S in tumor cells.